TABLE OF CONTENTS I
LIST OF FIGURES XVIII
LIST OF CHARTS XX
EXECUTIVE SUMMARY 1
U.S. ORTHOPEDIC BIOMATERIALS MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 4
MARKET TRENDS 6
MARKET DEVELOPMENTS 8
PROCEDURE NUMBERS 9
MARKETS INCLUDED 11
KEY REPORT UPDATES 13
VERSION HISTORY 13
RESEARCH METHODOLOGY 14
1.1 RESEARCH SCOPE 14
1.2 IDATA’S 9-STEP METHODOLOGY 14
Step 1: Project Initiation & Team Selection 14
Step 2: Prepare Data Systems and Perform Secondary Research 16
Step 3: Preparation for Interviews & Questionnaire Design 17
Step 4: Performing Primary Research 18
Step 5: Research Analysis: Establishing Baseline Estimates 20
Step 6: Market Forecast and Analysis 21
Step 7: Identify Strategic Opportunities 23
Step 8: Final Review and Market Release 24
Step 9: Customer Feedback and Market Monitoring 25
DISEASE OVERVIEW 26
2.1 BASIC ANATOMY 26
2.1.1 Osteology and Musculoskeletal System 26
2.2 DISEASE PATHOLOGY AND DISORDERS 28
2.2.1 General Diagnostic 28
2.2.2 Osteoporosis 29
2.2.3 Osteoarthritis 29
2.2.4 Indication for Bone Graft Procedure 30
2.2.5 Indication for Cartilage Repair 31
2.2.6 Degenerative Disc Disease 32
2.3 PATIENT DEMOGRAPHICS 34
2.3.1 General Statistics 34
PRODUCT ASSESSMENT 36
3.1 PRODUCT PORTFOLIOS 36
3.1.1 Hyaluronic Acid Viscosupplementation 37
3.2 REGULATORY ISSUES AND RECALLS 40
3.2.1 Hyaluronic Acid Viscosupplementation 40
3.3 CLINICAL TRIALS 41
3.3.1 Hyaluronic Acid Viscosupplementation 41
ORTHOPEDIC HYALURONIC ACID VISCOSUPPLEMENTATION MARKET 45
4.1 INTRODUCTION 45
4.1.1 Benefits of Viscosupplementation 46
4.1.2 Synovial Fluid 46
4.1.3 Product Types 47
4.1.3.1 Single-Injection Products 47
4.1.3.2 Two-Injection Cycle Products 47
4.1.3.3 Three-Injection Cycle Products 47
4.1.3.4 Three/Five-Injection Cycle Products 48
4.1.4 Reimbursement 48
4.2 MARKET OVERVIEW 49
4.3 MARKET ANALYSIS AND FORECAST 53
4.3.1 Total Hyaluronic Acid Viscosupplementation Market 53
4.3.1.1 Single-Injection Hyaluronic Acid Viscosupplementation Market 55
4.3.1.2 Three-Injection Hyaluronic Acid Viscosupplementation Market 57
4.3.1.3 Five-Injection Hyaluronic Acid Viscosupplementation Market 59
4.4 DRIVERS AND LIMITERS 61
4.4.1 Market Drivers 61
4.4.2 Market Limiters 62
4.5 COMPETITIVE MARKET SHARE ANALYSIS 64
ABBREVIATIONS 68
APPENDIX II: COMPANY PRESS RELEASES 70

Chart 1 1: Orthopedic Biomaterials Market by Segment, U.S., 2013 – 2023 3
Chart 1 2: Orthopedic Biomaterials Market Overview, U.S., 2016 & 2023 3
Chart 4 1: Orthopedic Hyaluronic Acid Viscosupplementation Market by Segment, U.S., 2013 – 2023 51
Chart 4 2: Orthopedic Hyaluronic Acid Viscosupplementation Market Breakdown, U.S., 2016 52
Chart 4 3: Orthopedic Hyaluronic Acid Viscosupplementation Market Breakdown, U.S., 2023 52
Chart 4 4: Total Hyaluronic Acid Viscosupplementation Market, U.S., 2013 – 2023 54
Chart 4 5: Single-Injection Hyaluronic Acid Viscosupplementation Market, U.S., 2013 – 2023 56
Chart 4 6: Three-Injection Hyaluronic Acid Viscosupplementation Market, U.S., 2013 – 2023 58
Chart 4 7: Five-Injection Hyaluronic Acid Viscosupplementation Market, U.S., 2013 – 2023 60
Chart 4 8: Leading Competitors, Orthopedic Hyaluronic Acid Viscosupplementation Market, U.S., 2016 67

Figure 1 1: Orthopedic Biomaterials Market Share Ranking by Segment, U.S., 2016 (1 of 2) 4
Figure 1 2: Orthopedic Biomaterials Market Share Ranking by Segment, U.S., 2016 (2 of 2) 4
Figure 1 3: Companies Researched in this Report, U.S., 2016 5
Figure 1 4: Factors Impacting the Orthopedic Biomaterials Market by Segment, U.S. (1 of 2) 6
Figure 1 5: Factors Impacting the Orthopedic Biomaterials Market by Segment, U.S. (2 of 2) 7
Figure 1 6: Recent Events in the Orthopedic Biomaterials Market, U.S., 2013 – 2016 8
Figure 1 7: Orthopedic Biomaterials Markets Covered, U.S., 2016 (1 of 2) 9
Figure 1 8: Orthopedic Biomaterials Markets Covered, U.S., 2016 (2 of 2) 10
Figure 1 9: Orthopedic Biomaterials Markets Covered, U.S., 2016(1 of 3) 11
Figure 3 1: Hyaluronic Acid Viscosupplementationby Products by Company 39
Figure 3 2: Class 3 Device Recall Euflexxa (1 sodium hyaluronate) 40
Figure 3 3: Trial Comparing Botulin Toxin Versus Hyaluronic Acid by Intra-articular Injection (GOTOX) 41
Figure 3 4: Trial to Assess the Structural Effect and Long-term Symptomatic Relief of Intra-articular Injections of HA (ViscOA) 41
Figure 3 5: Platelet-rich Plasma vs. Hyaluronic Acid for Glenohumeral Osteoarthritis 41
Figure 3 6: Comparative Assessment of Viscosupplementation With Polynucleotides and Hyaluronic Acid (PNHA1401) 42
Figure 3 7: To Look at the Characteristics of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection 42
Figure 3 8: Platelet-rich Plasma vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology (PRP) 43
Figure 3 9: Platelet-Rich Plasma Intra-Articular Injection in Treating Hemophilic Arthropathy 44
Figure 3 10: Effectiveness of Two Hyaluronic Acids in Osteoarthritis of the Knee 44
Figure 4 1: Orthopedic Hyaluronic Acid Viscosupplementation Market by Segment, U.S., 2013 – 2023 (US$M) 50
Figure 4 2: Total Hyaluronic Acid Viscosupplementation Market, U.S., 2013 – 2023 53
Figure 4 3: Single-Injection Hyaluronic Acid Viscosupplementation Market, U.S., 2013 – 2023 55
Figure 4 4: Three-Injection Hyaluronic Acid Viscosupplementation Market, U.S., 2013 – 2023 57
Figure 4 5: Five-Injection Hyaluronic Acid Viscosupplementation Market, U.S., 2013 – 2023 59
Figure 4 6: Drivers and Limiters, Orthopedic Hyaluronic Acid Viscosupplementation Market, U.S., 2016 63
Figure 4 7: Leading Competitors, Orthopedic Hyaluronic Acid Viscosupplementation Market, U.S., 2016 66
Figure 6 1: Press Release Summary 70

Medtronic
Genzyme
DePuy Synthes
Anika Therapeutics
Ferring Pharmaceuticals
Stryker
NuVasive
Bioventus
Zimmer Biomet
Integra LifeSciences
RTI Surgical
Fidia Pharmaceuticals
MTF
Orthofix
Arthrex
AlloSource
Aastrom
Baxter
Harvest Technologies
Wright Medical
Bacterin International
Arteriocyte
Exactech
LifeNet Health
Biocomposites
Alphatec Spine
Celling Biosciences
Globus Medical
Nuo Therapeutics
K2M
*Not all companies are currently active in every segment or sub-report from this suite. For more details contact an iData Research Product Advisor.