TABLE OF CONTENTS I
LIST OF FIGURES XI
LIST OF CHARTS XVII
EXECUTIVE SUMMARY 1
U.S. MINIMALLY INVASIVE SPINAL IMPLANT MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 3
MARKET TRENDS 6
MARKET DEVELOPMENTS 8
PROCEDURE NUMBERS 9
PROCEDURE CODES INVESTIGATED 10
MARKETS INCLUDED 11
VERSION HISTORY 11
RESEARCH METHODOLOGY 12
Step 1: Project Initiation & Team Selection 12
Step 2: Prepare Data Systems and Perform Secondary Research 15
Step 3: Preparation for Interviews & Questionnaire Design 17
Step 4: Performing Primary Research 18
Step 5: Research Analysis: Establishing Baseline Estimates 20
Step 6: Market Forecast and Analysis 21
Step 7: Identify Strategic Opportunities 23
Step 8: Final Review and Market Release 24
Step 9: Customer Feedback and Market Monitoring 25
DISEASE OVERVIEW 26
2.1 INTRODUCTION 26
2.1.1 Degenerative Disc Disease 26
2.1.1.1 Disc Herniation 26
2.1.1.2 Stenosis 27
2.1.1.3 Spondyloisthesis 28
2.1.1.4 Arthritis 28
2.1.2 Spinal Deformities 28
2.1.2.1 Scoliosis 28
2.1.2.2 Kyphosis and Lordosis 29
2.1.3 Trauma and Tumor 30
2.1.4 Vertebral Compression Fractures 30
2.1.4.1 Osteoporosis 30
2.1.4.2 Vertebral Compression Fractures 31
PRODUCT ASSESSMENT 32
3.1 INTRODUCTION 32
3.2 PRODUCT PORTFOLIOS 32
3.2.1 Cervical Fixation 32
3.2.1.1 Anterior Cervical Fixation 33
3.2.1.1.1 Constrained 33
3.2.1.1.2 Semi-Constrained 33
3.2.1.1.3 Dynamic 33
3.2.1.1.4 Bioresorbable 34
3.2.1.2 Posterior Cervical Fixation 34
3.2.2 Thoracolumbar Fixation 37
3.2.2.1 Traditional Systems 37
3.2.2.2 Minimally Invasive Systems 37
3.2.3 Interbody Devices 42
3.2.3.1 Approaches 42
3.2.3.1.1 ALIF 42
3.2.3.1.2 PLIF 43
3.2.3.1.3 TLIF 43
3.2.3.1.4 Minimally Invasive PLIF 43
3.2.3.1.5 Minimally Invasive TLIF 44
3.2.3.1.6 LLIF 44
3.2.3.1.7 OLIF 44
3.2.3.1.8 Cervical 44
3.2.3.1.9 VBR/Corpectomy 45
3.2.3.2 Materials 45
3.2.3.2.1 Metal 45
3.2.3.2.2 PEEK 45
3.2.3.2.3 Machined Bone Allograft 45
3.2.4 Motion Preservation Devices 51
3.2.4.1.1 Artificial Discs 51
3.2.4.1.2 Dynamic Stabilization 51
3.2.4.1.3 Nucleus Replacement 52
3.2.4.1.4 Facet Arthroplasty 52
3.2.5 Spinous Process Fixation 55
3.2.6 Facet Fixation 57
3.2.7 MIS Sacroiliac Joint Fusion 59
3.2.8 Vertebral Compression Fracture Devices 61
3.2.8.1.1 Percutaneous Vertebroplasty 61
3.2.8.1.2 Percutaneous Vertebral Augmentation Including Kyphoplasty 62
3.2.9 Spine Endoscopes 64
3.2.10 Spinal Electrical Stimulation Devices 66
3.3 PRODUCT PIPELINES 68
3.3.1 Nexxt Spine 68
3.3.1.1 SAXXONY™ Posterior Cervical Thoracic System 68
3.3.1.2 NEXXT MATRIXX™ Cervical Interbody/VBR System 68
3.3.2 NLT Spine/SeaSpine 69
3.3.2.1 PROW FUSION-V™ - Expandable Intervertebral Fusion Device 69
3.3.2.2 PROW FUSION-L™ - Lateral Intervertebral Fusion Device 69
3.3.2.3 SIJ- Expandable Screw 69
3.3.3 SpineArt 69
3.3.3.1 PERLA® 69
3.3.3.2 OTELO®LL 69
3.3.4 SpineFrontier 70
3.3.4.1 SIJ-Fuse Rod 70
3.3.4.2 SIJ-Fuse Screw 70
3.3.4.3 VBR 70
3.3.4.4 PedFuse Rely 70
3.3.4.5 LESplasty 70
3.3.4.6 Expanding P-LIFT 70
3.4 DISRUPTIVE TECHNOLOGIES 71
3.4.1 3D Printed Implants 71
3.4.2 Endoscopic Spine Surgery 72
3.4.3 Metallurgy/Alloy of Instrumentation 72
3.4.4 Nanotechnology Use in Spinal Implants 72
3.4.5 Operating Room Automation and Connectivity 73
3.5 FDA RECALLS 74
3.5.1 Alphatec Spine 74
3.5.2 Amedica 75
3.5.3 Back 2 Basics Direct 75
3.5.4 DePuy Synthes 76
3.5.5 Innovasis 77
3.5.6 Interventional Spine 78
3.5.7 Kiscomedica 78
3.5.8 Medacta 79
3.5.9 Medtronic 79
3.5.10 Neuropro Spinal Jaxx 82
3.5.11 Orthofix 82
3.5.12 OrthoPediatrics Corp 84
3.5.13 SpineArt 85
3.5.14 Stryker 85
3.5.15 Ulrich Medical USA Inc 87
3.5.16 XTANT MEDICAL INC 87
3.5.17 Zimmer Biomet 88
3.6 CLINICAL TRIALS 90
3.6.1 DePuy Synthes 90
3.6.2 Duke University 91
3.6.3 Globus Medical 91
3.6.4 Hamilton Health Sciences 92
3.6.5 K2M (Stryker) 92
3.6.6 Medtronic 93
3.6.7 Nexxt Spine 96
3.6.8 RTI Surgical 97
3.6.9 Stryker 97
3.6.10 Orthofix 98
3.6.11 Premia Spine 99
3.6.12 Zimmer Biomet 99
U.S. MINIMALLY INVASIVE SPINAL IMPLANT MARKET OVERVIEW 101
4.1 INTRODUCTION 101
4.1.1 Minimally Invasive Interbody Fusion 101
4.1.1.1 Minimally Invasive Transforaminal Lumbar Interbody Fusion 102
4.1.1.2 Minimally Invasive Posterior Lumbar Interbody Fusion 103
4.1.1.3 Lateral Lumbar Interbody Fusion 103
4.1.1.4 Oblique Lumbar Interbody Fusion 104
4.1.2 Minimally Invasive Surgery Pedicle Screws 104
4.1.2.1 Percutaneous MIS Systems 104
4.1.2.2 Retractor-Based MIS Systems 104
4.1.3 Spinous Process Fixation 105
4.1.4 Facet Fixation 105
4.1.5 MIS Sacroiliac Joint Fusion 105
4.1.6 MIS Spine Endoscopes 106
4.2 MARKET OVERVIEW 107
4.3 TREND ANALYSIS BY SEGMENT 112
4.4 DRIVERS AND LIMITERS 116
4.4.1 Market Drivers 116
4.4.2 Market Limiters 117
4.5 COMPETITIVE MARKET SHARE ANALYSIS 119
4.6 MERGERS AND ACQUISITIONS 126
4.7 COMPANY PROFILES 130
4.7.1 Aesculap (B. Braun) 130
4.7.2 Alphatec Spine 131
4.7.3 CTL Amedica (SINTX Technologies, Inc.) 132
4.7.4 DePuy Synthes 134
4.7.5 DJO Global 135
4.7.6 Globus Medical 136
4.7.7 K2M (Stryker) 137
4.7.8 Medtronic 138
4.7.9 NuVasive 140
4.7.10 Orthofix 141
4.7.11 SI-BONE 142
4.7.12 Stryker 143
4.7.13 Zimmer Biomet 144
4.8 SWOT ANALYSIS 146
4.8.1 Aesculap (B. Braun) 146
4.8.2 Alphatec Spine 147
4.8.3 CTL Amedica (SINTX Technologies, Inc.) 148
4.8.4 DePuy Synthes 149
4.8.5 DJO Global 150
4.8.6 Globus Medical 151
4.8.7 Medtronic 153
4.8.8 NuVasive 154
4.8.9 Orthofix 155
4.8.10 SI-BONE 156
4.8.11 Stryker 157
4.8.12 Zimmer Biomet 158
PROCEDURE NUMBERS 160
5.1 INTRODUCTION 160
5.2 PROCEDURES 162
5.2.1 Minimally Invasive Spinal Procedures 162
5.2.2 MIS Interbody Device Procedures 167
5.2.2.1 Total MIS Interbody Device Procedures 167
5.2.2.1.1 Total Levels Treated by MIS Interbody Device 169
5.2.2.2 MIPLIF Procedures 171
5.2.2.3 MITLIF Procedures 172
5.2.2.4 LLIF Procedures 173
5.2.2.5 OLIF Procedures 174
5.2.3 MIS Pedicle Screw Procedures 175
5.2.3.1 Total MIS Pedicle Screw Procedures 175
5.2.3.1.1 Total Levels Treated by MIS Pedicle Screw 177
5.2.3.2 Percutaneous Cannulated Pedicle Screw Procedures 179
5.2.3.3 Retractor Cannulated Pedicle Screw Procedures 180
5.2.3.4 Retractor Non-Cannulated Pedicle Screw Procedures 181
5.2.4 Spinous Process Fixation Procedures 182
5.2.5 Facet Fixation Procedures 184
5.2.6 MIS Sacroiliac Joint Fusion Procedures 186
5.2.7 Spine Endoscope Procedures 188
MIS INTERBODY DEVICE MARKET 190
6.1 INTRODUCTION 190
6.1.1 Approach Types 191
6.1.1.1 Minimally Invasive Posterior Lumbar Interbody Fusion 191
6.1.1.2 Minimally Invasive Transforaminal Lumbar Interbody Fusion 191
6.1.1.3 Lateral Lumbar Interbody Fusion 192
6.1.1.4 Direct Lateral Interbody Fusion 192
6.1.1.5 eXtreme Lateral Interbody Fusion 192
6.1.1.6 Guided Lateral Interbody Fusion 193
6.1.1.7 Oblique Lateral Interbody Fusion 193
6.2 MARKET OVERVIEW 194
6.3 MARKET ANALYSIS AND FORECAST 199
6.3.1 Total MIS Interbody Device Market 199
6.3.2 MIPLIF Market 201
6.3.3 MITLIF Market 204
6.3.4 LLIF Market 207
6.3.5 OLIF Market 210
6.4 DRIVERS AND LIMITERS 213
6.4.1 Market Drivers 213
6.4.2 Market Limiters 214
6.5 COMPETITIVE MARKET SHARE ANALYSIS 216
MIS PEDICLE SCREW MARKET 222
7.1 INTRODUCTION 222
7.1.1 Percutaneous MIS Systems 222
7.1.2 Retractor-Based MIS Systems 223
7.2 MARKET OVERVIEW 224
7.3 MARKET ANALYSIS AND FORECAST 229
7.3.1 Total MIS Pedicle Screw Market 229
7.3.2 Percutaneous Cannulated Pedicle Screw Market 231
7.3.3 Retractor Cannulated Pedicle Screw Market 234
7.3.4 Retractor Non-Cannulated Pedicle Screw Market 237
7.4 DRIVERS AND LIMITERS 240
7.4.1 Market Drivers 240
7.4.2 Market Limiters 241
7.5 COMPETITIVE MARKET SHARE ANALYSIS 243
SPINOUS PROCESS FIXATION MARKET 248
8.1 INTRODUCTION 248
8.2 MARKET ANALYSIS AND FORECAST 249
8.3 DRIVERS AND LIMITERS 252
8.3.1 Market Drivers 252
8.3.2 Market Limiters 253
8.4 COMPETITIVE MARKET SHARE ANALYSIS 255
FACET FIXATION MARKET 259
9.1 INTRODUCTION 259
9.2 MARKET ANALYSIS AND FORECAST 260
9.3 DRIVERS AND LIMITERS 263
9.3.1 Market Drivers 263
9.3.2 Market Limiters 264
9.4 COMPETITIVE MARKET SHARE ANALYSIS 266
SI JOINT FUSION MARKET 270
10.1 INTRODUCTION 270
10.2 MARKET ANALYSIS AND FORECAST 272
10.3 DRIVERS AND LIMITERS 275
10.3.1 Market Drivers 275
10.3.2 Market Limiters 276
10.4 COMPETITIVE MARKET SHARE ANALYSIS 279
SPINE ENDOSCOPE MARKET 283
11.1 INTRODUCTION 283
11.2 MARKET OVERVIEW 284
11.3 MARKET ANALYSIS AND FORECAST 289
11.3.1 Endoscope Market 289
11.3.2 Instrumentation Market 291
11.4 DRIVERS AND LIMITERS 293
11.4.1 Market Drivers 293
11.4.2 Market Limiters 294
11.5 COMPETITIVE MARKET SHARE ANALYSIS 296
MINIMALLY INVASIVE SPINAL SURGERY INSTRUMENTATION MARKET 299
12.1 INTRODUCTION 299
12.2 MARKET ANALYSIS AND FORECAST 300
12.3 DRIVERS AND LIMITERS 303
12.3.1 Market Drivers 303
12.3.2 Market Limiters 304
12.4 COMPETITIVE MARKET SHARE ANALYSIS 306
ABBREVIATIONS 309

Chart 1 1: Minimally Invasive Spinal Implant Market by Segment, U.S., 2015 – 2025 2
Chart 1 2: Minimally Invasive Spinal Implant Market Overview, U.S., 2018 & 2025 2
Chart 4 1: Minimally Invasive Spinal Implant Market by Segment, U.S., 2015 – 2025 109
Chart 4 2: Minimally Invasive Spinal Implant Market Breakdown, U.S., 2018 110
Chart 4 3: Minimally Invasive Spinal Implant Market Breakdown, U.S., 2025 111
Chart 4 4: Growth Rates by Segment, Minimally Invasive Spinal Implant Market, U.S., 2015 – 2025 115
Chart 4 5: Leading Competitors, Minimally Invasive Spinal Implant Market, U.S., 2018 125
Chart 5 1: Minimally Invasive Spinal Implant Procedures by Segment, U.S., 2015 – 2025 164
Chart 5 2: Levels Treated by Minimally Invasive Spinal Implant Procedures by Segment, U.S., 2015 – 2025 166
Chart 5 3: MIS Interbody Device Procedures by Segment, U.S., 2015 – 2025 168
Chart 5 4: Total MIS Interbody Device Levels Treated, U.S., 2015 – 2025 170
Chart 5 5: Total MIS Pedicle Screw Procedures by Segment, U.S., 2015 – 2025 176
Chart 5 6: Total MIS Pedicle Screw Levels Treated by Segment, U.S., 2015 – 2025 178
Chart 5 7: Total Spinous Process Fixation Procedures, U.S., 2015 – 2025 183
Chart 5 8: Facet Fixation Procedures, U.S., 2015 – 2025 185
Chart 5 9: MIS Sacroiliac Joint Fusion Procedures, U.S., 2015 – 2025 187
Chart 5 10: Spine Endoscope Procedures, U.S., 2015 – 2025 189
Chart 6 1: MIS Interbody Device Market by Segment, U.S., 2015 – 2025 196
Chart 6 2: MIS Interbody Device Market Breakdown, U.S., 2018 197
Chart 6 3: MIS Interbody Device Market Breakdown, U.S., 2025 198
Chart 6 4: MIS Interbody Device Market, U.S., 2015 – 2025 200
Chart 6 5: MIPLIF Market, U.S., 2015 – 2025 203
Chart 6 6: MITLIF Market, U.S., 2015 – 2025 206
Chart 6 7: LLIF Market, U.S., 2015 – 2025 209
Chart 6 8: OLIF Market, U.S., 2015 – 2025 212
Chart 6 9: Leading Competitors, MIS Interbody Device Market, U.S., 2018 221
Chart 7 1: MIS Pedicle Screw Market by Segment, U.S., 2015 – 2025 226
Chart 7 2: MIS Pedicle Screw Market Breakdown, U.S., 2018 227
Chart 7 3: MIS Pedicle Screw Market Breakdown, U.S., 2025 228
Chart 7 4: MIS Pedicle Screw Market, U.S., 2015 – 2025 230
Chart 7 5: Percutaneous Cannulated Pedicle Screw Market, U.S., 2015 – 2025 233
Chart 7 6: Retractor Cannulated Pedicle Screw Market, U.S., 2015 – 2025 236
Chart 7 7: Retractor Non-Cannulated Pedicle Screw Market, U.S., 2015 – 2025 239
Chart 7 8: Leading Competitors, MIS Pedicle Screw Market, U.S., 2018 247
Chart 8 1: Spinous Process Fixation Market, U.S., 2015 – 2025 251
Chart 8 2: Leading Competitors, Spinous Process Fixation Market, U.S., 2018 258
Chart 9 1: Facet Fixation Market, U.S., 2015 – 2025 262
Chart 9 2: Leading Competitors, Facet Fixation Market, U.S., 2018 269
Chart 10 1: SI Joint Fusion Market, U.S., 2015 – 2025 274
Chart 10 2: Leading Competitors, SI Joint Fusion Market, U.S., 2018 282
Chart 11 1: Spine Endoscope Market by Segment, U.S., 2015 – 2025 286
Chart 11 2: Spine Endoscope Market Breakdown, U.S., 2018 287
Chart 11 3: Spine Endoscope Market Breakdown, U.S., 2025 288
Chart 11 4: Endoscope Market, U.S., 2015 – 2025 290
Chart 11 5: Instrumentation Market, U.S., 2015 – 2025 292
Chart 11 6: Leading Competitors, Spine Endoscope Market, U.S., 2018 298
Chart 12 1: Minimally Invasive Spinal Surgery Instrumentation Market, U.S., 2015 – 2025 302

Figure 1 1: Minimally Invasive Spinal Implant Market Share Ranking by Segment, U.S., 2018 (1 of 2) 3
Figure 1 2: Minimally Invasive Spinal Implant Market Share Ranking by Segment, U.S., 2018 (2 of 2) 4
Figure 1 3: Companies Researched in this Report, U.S., 2018 5
Figure 1 4: Factors Impacting the Minimally Invasive Spinal Implant Market by Segment, U.S. (1 of 2) 6
Figure 1 5: Factors Impacting the Minimally Invasive Spinal Implant Market by Segment, U.S. (2 of 2) 7
Figure 1 6: Recent Events in the Minimally Invasive Spinal Implant Market, U.S., 2017 – 2019 8
Figure 1 7: Minimally Invasive Spinal Implant Procedures Covered, U.S., 2018 9
Figure 1 8: Procedure Codes Investigated, U.S., 2018 (1 of 2) 10
Figure 1 9: Minimally Invasive Spinal Implant Markets Covered, U.S., 2018 11
Figure 1 10: Version History 11
Figure 3 1: Cervical Fixation Devices by Company (1 of 2) 35
Figure 3 2: Cervical Fixation Devices by Company (2 of 2) 36
Figure 3 3: Thoracolumbar Fixation Devices by Company (1 of 4) 38
Figure 3 4: Thoracolumbar Fixation Devices by Company (2 of 4) 39
Figure 3 5: Thoracolumbar Fixation Devices by Company (3 of 4) 40
Figure 3 6: Thoracolumbar Fixation Devices by Company (4 of 4) 41
Figure 3 7: Interbody Devices by Company (1 of 5) 46
Figure 3 8: Interbody Devices by Company (2 of 5) 47
Figure 3 9: Interbody Devices by Company (3 of 5) 48
Figure 3 10: Interbody Devices by Company (4 of 5) 49
Figure 3 11: Interbody Devices by Company (5 of 5) 50
Figure 3 12: Cervical Artificial Disc Devices by Company 53
Figure 3 13: Lumbar Artificial Disc Devices by Company 54
Figure 3 14: Dynamic Posterior Stabilization Devices by Company 54
Figure 3 15: Interspinous Process Decompression Devices by Company 54
Figure 3 16: Spinous Process Fixation Devices by Company 56
Figure 3 17: Facet Fixation Devices by Company 58
Figure 3 18: MIS Sacroiliac Joint Devices by Company 60
Figure 3 19: Vertebral Compression Fracture Devices by Company 63
Figure 3 20: Spine Endoscopes by Company 65
Figure 3 21: Spinal Electrical Stimulation Devices by Company 67
Figure 3 22: Class 2 Device Recall ELAN 4 Air System 74
Figure 3 23: Class 2 Device Recall Alphatec Spine 74
Figure 3 24: Class 2 Device Recall Omni Spine Anterior Cervical Plate System 75
Figure 3 25: Class 2 Device Recall Dymaxeon Spine System 75
Figure 3 26: Class 2 Device Recall Concorde Lift 76
Figure 3 27: Device Recall MODEL: Aegis Torque Handle CATALOG NO. : 287110800 76
Figure 3 28: Class 2 Device Recall Synthes Flex Arm 76
Figure 3 29: Class 2 Device Recall Concorde Lift 77
Figure 3 30: Class 2 Device Recall DePuy Synthes 77
Figure 3 31: Class 2 Device Recall Opteryx Variable Rescue Screw 77
Figure 3 32: Class 2 Device Recall G3 Opticage Expandable Interbody Fusion Device 78
Figure 3 33: Class 2 Device Recall LVarlock Cage/Trial Implant Holder 78
Figure 3 34: Class 2 Device Recall M.U.S.T. Rod 79
Figure 3 35: Class 2 Device Recall Specify neurostimulation leads 79
Figure 3 36: Class 2 Device Recall Spinous Process Clamp 80
Figure 3 37: Class 2 Device Recall StealthStation System 80
Figure 3 38: Class 2 Device Recall Medtronic Navigated Solera Screwdrivers 80
Figure 3 39: Class 2 Device Recall Medtronic Navigated Cannulated Taps 81
Figure 3 40: Class 2 Device Recall Medtronic CD HORIZON Spinal System MULTIAXIAL SCREW FOR 5.5/6.0MM RODS 81
Figure 3 41: Class 2 Device Recall Spinal Jaxx Interbody Fusion Device 82
Figure 3 42: Class 2 Device Recall Manual General Surgery Drill Guide 82
Figure 3 43: Class 2 Device Recall Firebird NXG Spinal Fixation System Set Screw Driver 83
Figure 3 44: Class 2 Device Recall Firebird Spinal Fixation System 83
Figure 3 45: Class 2 Device Recall Rod and screw spinal instrumentation 83
Figure 3 46: Class 2 Device Recall Response BandLoc 5.5/6.0 Tensioner Instrument 84
Figure 3 47: Class 2 Device Recall thoracolumbosacral pedicle screw system 84
Figure 3 48: Class 2 Device Recall TRYPTIK(R) 2 CPLATE SELFTAPPING POLYAXIAL SCREW 85
Figure 3 49: Class 2 Device Recall AVS Aria Cage 85
Figure 3 50: Class 2 Device Recall Reprocessed HARMONIC Ace 7, 5mm Diameter Shears with Advanced Hemostasis (HARH) 86
Figure 3 51: Class 2 Device Recall Stryker Spine 86
Figure 3 52: Class 2 Device Recall UniVise Inserter 86
Figure 3 53: Class 2 Device Recall uNion CPS 87
Figure 3 54: Class 2 Device Recall Calix Lumbar Spinal Implant System 87
Figure 3 55: Class 2 Device Recall Fortex Pedicle Screw System 88
Figure 3 56: Class 2 Device Recall Altius MINI OCT Posterior Spinal Fixation System 88
Figure 3 57: Class 2 Device Recall Zimmer Biomet 88
Figure 3 58: Class 3 Device Recall Zimmer Biomet Spine 89
Figure 3 59: An ACDF Multi-Center Study Using ViviGen Cellular Bone Matrix 90
Figure 3 60: ACDF Comparison Trial 91
Figure 3 61: A Retrospective Study Using CALIBER® TLIF Expandable Spacer in the Treatment of DDD: 2 Year Follow-up. 91
Figure 3 62: To Brace or Not to Brace for Single Level Lumbar Fusion Pilot (BRACE Pilot). 92
Figure 3 63: Comparing Pedicle Screw Systems for the Treatment of Adolescent Paediatric Spine Deformity 92
Figure 3 64: An Investigation of the Metal Concentration in Patients Implanted With the PRESTIGE LP™ Cervical Disc 93
Figure 3 65: A Prospective, 5-Year Global Study on MAST™ 94
Figure 3 66: OLIF25™ /OLIF51™ Study 94
Figure 3 67: Spinal Cord Stimulation to Treat Post-operative Atrial Fibrillation (SCS-PAF) 95
Figure 3 68: Fenestrated Screw Study (FNS) 95
Figure 3 69: Lumbar Fusion With Nexxt Spine 3D-Printed Titanium Interbody Cages 96
Figure 3 70: ViBone in Cervical and Lumbar Spine Fusion 97
Figure 3 71: BIO4 Clinical Case Study: Cervical Spine 97
Figure 3 72: AccuLIF® PROSPECTIVE PATIENT OUTCOMES STUDY (APROPOS) 98
Figure 3 73: Study Using the SpinalStim Device Following Lumbar Fusion Surgery 98
Figure 3 74: A Pivotal Study of the Premia Spine TOPS™ System 99
Figure 3 75: Radiological and Clinical Efficacy of a Hybrid Spinal Implant ("Topping Off"): a Mono-center, Prospective Clinical Trial 99
Figure 3 76: Post-Market Surveillance Study of the TM Ardis Interbody Fusion System 100
Figure 4 1: Minimally Invasive Spinal Implant Market by Segment, U.S., 2015 – 2025 (US$M) 108
Figure 4 2: Minimally Invasive Spinal Implant Market Growth by Segment, U.S., 2015 – 2025 114
Figure 4 3: Drivers and Limiters, Minimally Invasive Spinal Implant Market, U.S., 2018 118
Figure 4 4: Leading Competitors, Minimally Invasive Spinal Implant Market, U.S., 2018 124
Figure 4 5: SWOT Analysis, Aesculap (B. Braun) 146
Figure 4 6: SWOT Analysis, Alphatec Spine 147
Figure 4 7: SWOT Analysis, CTL Amedica (SINTX Technologies, Inc.) 148
Figure 4 8: SWOT Analysis, DePuy Synthes 149
Figure 4 9: SWOT Analysis, DJO Global 150
Figure 4 10: SWOT Analysis, Globus Medical (1 of 2) 151
Figure 4 11: SWOT Analysis, Globus Medical (2 of 2) 152
Figure 4 12: SWOT Analysis, Medtronic 153
Figure 4 13: SWOT Analysis, NuVasive 154
Figure 4 14: SWOT Analysis, Orthofix 155
Figure 4 15: SWOT Analysis, SI-BONE 156
Figure 4 16: SWOT Analysis, Stryker 157
Figure 4 17: SWOT Analysis, Zimmer Biomet (1 of 2) 158
Figure 4 18: SWOT Analysis, Zimmer Biomet (2 of 2) 159
Figure 5 1: Procedure Codes Investigated, U.S., 2018 161
Figure 5 2: Minimally Invasive Spinal Implant Procedures by Segment, U.S., 2015 – 2025 163
Figure 5 3: Levels Treated by Minimally Invasive Spinal Implant Procedures by Segment, U.S., 2015 – 2025 165
Figure 5 4: MIS Interbody Device Procedures by Segment, U.S., 2015 – 2025 167
Figure 5 5: Total Levels Treated by MIS Interbody Device, U.S., 2015 – 2025 169
Figure 5 6: MIPLIF Procedures, U.S., 2015 – 2025 171
Figure 5 7: MITLIF Procedures, U.S., 2015 – 2025 172
Figure 5 8: LLIF Procedures, U.S., 2015 – 2025 173
Figure 5 9: OLIF Procedures, U.S., 2015 – 2025 174
Figure 5 10: Total MIS Pedicle Screw Procedures by Segment, U.S., 2015 – 2025 175
Figure 5 11: Total Levels Treated by MIS Pedicle Screw, U.S., 2015 – 2025 177
Figure 5 12: Percutaneous Cannulated Pedicle Screw Procedures, U.S., 2015 – 2025 179
Figure 5 13: Retractor Cannulated Pedicle Screw Procedures, U.S., 2015 – 2025 180
Figure 5 14: Retractor Non-Cannulated Pedicle Screw Procedures, U.S., 2015 – 2025 181
Figure 5 15: Total Spinous Process Fixation Device Procedures, U.S., 2015 – 2025 182
Figure 5 16: Facet Fixation Procedures, U.S., 2015 – 2025 184
Figure 5 17: MIS Sacroiliac Joint Fusion Procedures, U.S., 2015 – 2025 186
Figure 5 18: Spine Endoscope Procedures, U.S., 2015 – 2025 188
Figure 6 1: MIS Interbody Device Market by Segment, U.S., 2015 – 2025 (US$M) 195
Figure 6 2: MIS Interbody Device Market, U.S., 2015 – 2025 199
Figure 6 3: MIPLIF Market, U.S., 2015 – 2025 202
Figure 6 4: MITLIF Market, U.S., 2015 – 2025 205
Figure 6 5: LLIF Market, U.S., 2015 – 2025 208
Figure 6 6: OLIF Market, U.S., 2015 – 2025 211
Figure 6 7: Drivers and Limiters, MIS Interbody Device Market, U.S., 2018 215
Figure 6 8: Leading Competitors, MIS Interbody Device Market, U.S., 2018 220
Figure 7 1: MIS Pedicle Screw Market by Segment, U.S., 2015 – 2025 (US$M) 225
Figure 7 2: MIS Pedicle Screw Market, U.S., 2015 – 2025 229
Figure 7 3: Percutaneous Cannulated Pedicle Screw Market, U.S., 2015 – 2025 232
Figure 7 4: Retractor Cannulated Pedicle Screw Market, U.S., 2015 – 2025 235
Figure 7 5: Retractor Non-Cannulated Pedicle Screw Market, U.S., 2015 – 2025 238
Figure 7 6: Drivers and Limiters, MIS Pedicle Screw Market, U.S., 2018 242
Figure 7 7: Leading Competitors, MIS Pedicle Screw Market, U.S., 2018 246
Figure 8 1: Spinous Process Fixation Market, U.S., 2015 – 2025 250
Figure 8 2: Drivers and Limiters, Spinous Process Fixation Market, U.S., 2018 254
Figure 8 3: Leading Competitors, Spinous Process Fixation Market, U.S., 2018 257
Figure 9 1: Facet Fixation Market, U.S., 2015 – 2025 261
Figure 9 2: Drivers and Limiters, Facet Fixation Market, U.S., 2018 265
Figure 9 3: Leading Competitors, Facet Fixation Market, U.S., 2018 268
Figure 10 1: SI Joint Fusion Market, U.S., 2015 – 2025 273
Figure 10 2: Drivers and Limiters, SI Joint Fusion Market, U.S., 2018 278
Figure 10 3: Leading Competitors, SI Joint Fusion Market, U.S., 2018 281
Figure 11 1: Spine Endoscope Market by Segment, U.S., 2015 – 2025 (US$M) 285
Figure 11 2: Endoscope Market, U.S., 2015 – 2025 289
Figure 11 3: Instrumentation Market, U.S., 2015 – 2025 291
Figure 11 4: Drivers and Limiters, Spine Endoscope Market, U.S., 2018 295
Figure 11 5: Leading Competitors, Spine Endoscope Market, U.S., 2018 297
Figure 12 1: Minimally Invasive Spinal Surgery Instrumentation Market, U.S., 2015 – 2025 301
Figure 12 2: Drivers and Limiters, Minimally Invasive Spinal Surgery Instrumentation Market, U.S., 2018 305
Figure 12 3: Leading Competitors, Minimally Invasive Spinal Surgery Instrumentation Market, U.S., 2018 308

Overall, the "Minimally Invasive Spinal Implant Market" includes analysis on the following companies:
ACTEON Group
Aesculap
Alphatec Spine
Amedica
Apiary Medical
Atlas Spine
Aurora Spine
Boss Instruments
Camber Spine
Captiva Spine
Centinel Spine
Clariance
CoreLink Surgical
DePuy Synthes
Genesys Spine
Globus Medical
GS Medical
gSource
Innomed
Integra LifeSciences
Joimax
Karl Storz
Life Instruments
Life Spine
Medacta International
*Not all companies may be currently active in every segment. For more details contact an iData Research Product Advisor.