TABLE OF CONTENTS I
LIST OF FIGURES IX
LIST OF CHARTS XI
EXECUTIVE SUMMARY 1
U.S. NEUROMODULATION, NEUROVASCULAR, NEUROSURGICAL AND MONITORING DEVICE MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 4
MARKET TRENDS 8
MARKET DEVELOPMENTS 11
PROCEDURE NUMBERS 12
PROCEDURE CODES INVESTIGATED 13
MARKETS INCLUDED 15
KEY REPORT UPDATES 17
VERSION HISTORY 17
RESEARCH METHODOLOGY 18
1.1 RESEARCH SCOPE 18
1.2 IDATA’S 9-STEP METHODOLOGY 18
Step 1: Project Initiation & Team Selection 18
Step 2: Prepare Data Systems and Perform Secondary Research 20
Step 3: Preparation for Interviews & Questionnaire Design 21
Step 4: Performing Primary Research 22
Step 5: Research Analysis: Establishing Baseline Estimates 24
Step 6: Market Forecast and Analysis 25
Step 7: Identify Strategic Opportunities 27
Step 8: Final Review and Market Release 28
Step 9: Customer Feedback and Market Monitoring 29
DISEASE OVERVIEW 30
2.1 BASIC ANATOMY 30
2.2 DISEASE PATHOLOGY AND DISORDERS 32
2.2.1 Introduction 32
2.2.2 General Diagnostics and Neurosurgery 34
2.2.3 Tumor and Brain Cancer 36
2.2.4 Brain Arteriovenous Malformations 38
2.2.5 Ischemic Stroke 39
2.2.6 Brain Aneurysm 40
2.2.7 Disorders Related to Cerebrospinal Fluids and Intracranial Pressure 42
2.2.7.1 Hydrocephalus and Intracranial Pressure Disorder 42
2.2.7.2 Cerebral Edema 43
2.2.8 Indication for Neuromodulation 45
2.2.9 Traumatic brain injury 47
PRODUCT ASSESSMENT 48
3.1 PRODUCT PORTFOLIOS 48
3.1.1 Neurovascular Stent 48
3.1.1.1 Introduction 48
3.1.1.2 Product Matrix for Neurovascular Stent Market: Core Companies 51
3.2 REGULATORY ISSUES AND RECALLS 52
3.2.1 Neurovascular Stent 52
3.3 CLINICAL TRIALS 53
3.3.1 Neurovascular Stent 53
NEUROVASCULAR STENT MARKET 57
4.1 INTRODUCTION 57
4.2 MARKET OVERVIEW 59
4.3 MARKET ANALYSIS AND FORECAST 62
4.3.1 Total Neurovascular Stent Market 62
4.3.2 Traditional Neurovascular Stent Market 64
4.3.3 Flow Diversion Stent Market 67
4.4 DRIVERS AND LIMITERS 69
4.4.1 Market Drivers 69
4.4.2 Market Limiters 70
4.5 COMPETITIVE MARKET SHARE ANALYSIS 72
ABBREVIATIONS 76
APPENDIX: COMPANY PRESS RELEASES 79

Chart 1 1: Neurological Device Market by Segment, U.S., 2013 – 2023 3
Chart 1 2: Neurological Device Market Overview, U.S., 2016 & 2023 3
Chart 4 1: Neurovascular Stent Market, U.S., 2013 – 2023 60
Chart 4 2: Neurovascular Stent Market Breakdown, U.S., 2016 61
Chart 4 3: Neurovascular Stent Market Breakdown, U.S., 2023 61
Chart 4 4: Total Neurovascular Stent Market, U.S., 2013 – 2023 63
Chart 4 5: Traditional Neurovascular Stent Market, U.S., 2013 – 2023 66
Chart 4 6: Flow Diversion Stent Market, U.S., 2013 – 2023 68
Chart 4 7: Leading Competitors, Neurovascular Stent Market, U.S., 2016 75

Figure 1 1: Neurological Device Market Share Ranking by Segment, U.S., 2016 (1 of 3) 5
Figure 1 2: Neurological Device Market Share Ranking by Segment, U.S., 2016 (2 of 3) 5
Figure 1 3: Neurological Device Market Share Ranking by Segment, U.S., 2016 (3 of 3) 6
Figure 1 4: Companies Researched in this Report, U.S., 2016 7
Figure 1 5: Factors Impacting the Neurological Device Market by Segment, U.S. (1 of 3) 8
Figure 1 6: Factors Impacting the Neurological Device Market by Segment, U.S. (2 of 3) 9
Figure 1 7: Factors Impacting the Neurological Device Market by Segment, U.S. (3 of 3) 10
Figure 1 8: Recent Events in the Neurological Device Market, U.S., 2014 – 2016 11
Figure 1 9: Neurological Device Markets Covered, U.S., 2016 12
Figure 1 10: Procedural Codes Investigated, U.S., 2016 (1 of 2) 13
Figure 1 11: Procedural Codes Investigated, U.S., 2016 (2 of 2) 14
Figure 1 12: Neurological Device Markets Covered, U.S., 2016 (1 of 2) 15
Figure 1 13: Neurological Device Markets Covered, U.S., 2016 (2 of 2) 16
Figure 1 14: Key Report Updates 17
Figure 1 15: Version History 17
Figure 2 1: Neurology Disease Overview 33
Figure 2 2: Brain/Other Nervous System Cancer Statistics by Type and Gender, U.S., 2016 37
Figure 3 1: Class 2 Device Recall: Pipeline and Pipeline Flex 52
Figure 3 2: Class 2 Device Recall: Stryker brand Neuroform 3 Microdelivery Stent System 52
Figure 3 3: Class 2 Device Recall: Wingspan Stent System 52
Figure 3 4: Neurovascular Stent: Safety and Effectiveness of an Intracranial Aneurysm Embolization System 53
Figure 3 5: Neurovascular Stent: Study of the Reverse Medical Barrel™ Vascular Reconstruction Device (VRD) 53
Figure 3 6: Neurovascular Stent: Flow Diverter Stent for Endovascular Treatment of Unruptured Saccular Wide-necked Intracranial Aneurysms (EVIDENCE) 54
Figure 3 7: Neurovascular Stent: Complete Occlusion of Coilable Aneurysms (COCOA) 54
Figure 3 8: Neurovasculr Stents: VISSIT Intracranial Stent Study for Ischemic Therapy (VISSIT) 55
Figure 3 9: Neurovasculr Stents: The Registry to Study Safety and Performance of the CORDIS Vascular Reconstruction Device and Delivery System (SUNRISE) 55
Figure 3 10: Neurovasculr Stents: Enterprise Stent Aneurysm Treatment (ESAT) Study - France (ESAT) 56
Figure 4 1: Neurovascular Stent Market, U.S., 2013 – 2023 (US$M) 59
Figure 4 2: Total Neurovascular Stent Market, U.S., 2013 – 2023 62
Figure 4 3: Traditional Neurovascular Stent Market, U.S., 2013 – 2023 65
Figure 4 4: Flow Diversion Stent Market, U.S., 2013 – 2023 67
Figure 4 5: Drivers and Limiters, Neurovascular Stent Market, U.S., 2016 71
Figure 4 6: Leading Competitors, Neurovascular Stent Market, U.S., 2016 74
Figure 6 1: Press Release Summary 79

Medtronic
Boston Scientific
St. Jude Medical
Cyberonics
Codman & Shurtleff
Stryker
Integra LifeSciences
InoMed
Mizuho America
RauMedic