TABLE OF CONTENTS I
LIST OF FIGURES IX
LIST OF CHARTS XI
EXECUTIVE SUMMARY 1
U.S. NEUROMODULATION, NEUROVASCULAR, NEUROSURGICAL AND MONITORING DEVICE MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 4
MARKET TRENDS 8
MARKET DEVELOPMENTS 11
PROCEDURE NUMBERS 12
PROCEDURE CODES INVESTIGATED 13
MARKETS INCLUDED 15
KEY REPORT UPDATES 17
VERSION HISTORY 17
RESEARCH METHODOLOGY 18
1.1 RESEARCH SCOPE 18
1.2 IDATA’S 9-STEP METHODOLOGY 18
Step 1: Project Initiation & Team Selection 18
Step 2: Prepare Data Systems and Perform Secondary Research 20
Step 3: Preparation for Interviews & Questionnaire Design 21
Step 4: Performing Primary Research 22
Step 5: Research Analysis: Establishing Baseline Estimates 24
Step 6: Market Forecast and Analysis 25
Step 7: Identify Strategic Opportunities 27
Step 8: Final Review and Market Release 28
Step 9: Customer Feedback and Market Monitoring 29
DISEASE OVERVIEW 30
2.1 BASIC ANATOMY 30
2.2 DISEASE PATHOLOGY AND DISORDERS 32
2.2.1 Introduction 32
2.2.2 General Diagnostics and Neurosurgery 34
2.2.3 Tumor and Brain Cancer 36
2.2.4 Brain Arteriovenous Malformations 38
2.2.5 Ischemic Stroke 39
2.2.6 Brain Aneurysm 40
2.2.7 Disorders Related to Cerebrospinal Fluids and Intracranial Pressure 42
2.2.7.1 Hydrocephalus and Intracranial Pressure Disorder 42
2.2.7.2 Cerebral Edema 43
2.2.8 Indication for Neuromodulation 45
2.2.9 Traumatic brain injury 47
PRODUCT ASSESSMENT 48
3.1 PRODUCT PORTFOLIOS 48
3.1.1 Ultrasonic Aspiration Devices 48
3.1.1.1 Introduction 48
3.1.1.2 Product Matrix for Ultraconic Aspiration Device: Core Companies 50
3.2 REGULATORY ISSUES AND RECALLS 51
3.2.1 Ultrasonic Aspiration 51
3.3 CLINICAL TRIALS 53
3.3.1 Ultrasonic Aspiration 53
ULTRASONIC ASPIRATOR MARKET 54
4.1 INTRODUCTION 54
4.2 MARKET ANALYSIS AND FORECAST 55
4.2.1 Ultrasonic Aspirator Market 55
4.2.2 Installed Base 58
4.2.3 Ultrasonic Aspirator Disposable Probe Tips 59
4.2.4 Ultrasonic Aspirator Disposable Tubing 61
4.3 DRIVERS AND LIMITERS 63
4.3.1 Market Drivers 63
4.3.2 Market Limiters 64
4.4 COMPETITIVE MARKET SHARE ANALYSIS 65
ABBREVIATIONS 68
APPENDIX: COMPANY PRESS RELEASES 71

Chart 1 1: Neurological Device Market by Segment, U.S., 2013 – 2023 3
Chart 1 2: Neurological Device Market Overview, U.S., 2016 & 2023 3
Chart 4 1: Ultrasonic Aspirator Market, U.S., 2013 – 2023 57
Chart 4 2: Ultrasonic Aspirator Disposable Probe Tip Market, U.S., 2013 – 2023 60
Chart 4 3: Ultrasonic Aspirator Disposable Tubing Market, U.S., 2013 – 2023 62
Chart 4 4: Leading Competitors, Ultrasonic Aspirator Market, U.S., 2016 67

Figure 1 1: Neurological Device Market Share Ranking by Segment, U.S., 2016 (1 of 3) 5
Figure 1 2: Neurological Device Market Share Ranking by Segment, U.S., 2016 (2 of 3) 5
Figure 1 3: Neurological Device Market Share Ranking by Segment, U.S., 2016 (3 of 3) 6
Figure 1 4: Companies Researched in this Report, U.S., 2016 7
Figure 1 5: Factors Impacting the Neurological Device Market by Segment, U.S. (1 of 3) 8
Figure 1 6: Factors Impacting the Neurological Device Market by Segment, U.S. (2 of 3) 9
Figure 1 7: Factors Impacting the Neurological Device Market by Segment, U.S. (3 of 3) 10
Figure 1 8: Recent Events in the Neurological Device Market, U.S., 2014 – 2016 11
Figure 1 9: Neurological Device Markets Covered, U.S., 2016 12
Figure 1 10: Procedural Codes Investigated, U.S., 2016 (1 of 2) 13
Figure 1 11: Procedural Codes Investigated, U.S., 2016 (2 of 2) 14
Figure 1 12: Neurological Device Markets Covered, U.S., 2016 (1 of 2) 15
Figure 1 13: Neurological Device Markets Covered, U.S., 2016 (2 of 2) 16
Figure 1 14: Key Report Updates 17
Figure 1 15: Version History 17
Figure 2 1: Neurology Disease Overview 33
Figure 2 2: Brain/Other Nervous System Cancer Statistics by Type and Gender, U.S., 2016 37
Figure 3 1: Class 2 Device Recall: Integra LifeSciences Corp. 51
Figure 3 2: Class 2 Device Recall: Sonopet Ultrasonic Aspirator Console, Stryker Corporation 51
Figure 3 3: Class 2 Device Recall: Integra CUSA Excel Sterile Torque Wrench (23 kHz) 52
Figure 3 4: Class 2 Device Recall: 52
Figure 3 5: Class 2 Device Recall: Integra CEM Nosecones 52
Figure 3 6: Ultrasonic Aspiration: European Registry on the ACE Reperfusion Catheters and the Penumbra System 53
Figure 4 1: Ultrasonic Aspirator Market, U.S., 2013 – 2023 56
Figure 4 2: Installed Base, Ultrasonic Aspirator Market, U.S., 2013 – 2023 58
Figure 4 3: Drivers and Limiters, Ultrasonic Aspirator Market, U.S., 2016 64
Figure 4 4: Leading Competitors, Ultrasonic Aspirator Market, U.S., 2016 66
Figure 6 1: Press Release Summary 71

Medtronic
Boston Scientific
St. Jude Medical
Cyberonics
Codman & Shurtleff
Stryker
Integra LifeSciences
InoMed
Mizuho America
RauMedic