General Report Contents
• Market Analyses include: Unit Sales, ASPs, Market Value & Growth Trends
• Market Drivers & Limiters for each chapter segment
• Competitive Analysis for each chapter segment
• Section on recent mergers & acquisitions
Market growth will be propelled by wider acceptance of neuromodulation products, allowing them to be used on a larger proportion of potential patients. As new devices are developed and more indications are able to be treated by neuromodulation devices, the patient population will increase, driving unit sales. The neuromodulation market had a relatively low penetration rate in 2016 and therefore has excellent growth potential.
Additionally, neuromodulation products require replacement when their batteries deplete, leading to continuing replacement sales. Many neuromodulation patients require multiple devices over their lifetimes because the battery life of neuromodulation devices is limited, ranging from three to ten years. One common trend across Europe is the desire for non-rechargeable neuromodulation devices due to their lower price since many countries in Europe are price sensitive with limited budgets. Over the forecast period there will be an increase in the percentage of rechargeable devices that will be used.
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TABLE OF CONTENTS I
LIST OF FIGURES XI
LIST OF CHARTS XIV
EXECUTIVE SUMMARY 1
EUROPEAN NEUROMODULATION, NEUROVASCULAR, NEUROSURGICAL AND MONITORING DEVICE MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 3
MARKET TRENDS 7
MARKET DEVELOPMENTS 10
MARKETS INCLUDED 11
PROCEDURES INCLUDED 12
KEY REPORT UPDATES 13
VERSION HISTORY 13
RESEARCH METHODOLOGY 14
1.1 RESEARCH SCOPE 14
1.2 IDATA’S 9-STEP METHODOLOGY 14
Step 1: Project Initiation & Team Selection 14
Step 2: Prepare Data Systems and Perform Secondary Research 16
Step 3: Preparation for Interviews & Questionnaire Design 17
Step 4: Performing Primary Research 18
Step 5: Research Analysis: Establishing Baseline Estimates 20
Step 6: Market Forecast and Analysis 21
Step 7: Identify Strategic Opportunities 23
Step 8: Final Review and Market Release 24
Step 9: Customer Feedback and Market Monitoring 25
DISEASE OVERVIEW 26
2.1 BASIC ANATOMY 26
2.2 DISEASE PATHOLOGY AND DISORDERS 28
2.2.1 Introduction 28
2.2.2 General Diagnostics and Neurosurgery 30
2.2.3 Tumor and Brain Cancer 32
2.2.4 Brain Arteriovenous Malformations 34
2.2.5 Ischemic Stroke 35
2.2.6 Brain Aneurysm 36
2.2.7 Disorders Related to Cerebrospinal Fluids and Intracranial Pressure 38
2.2.7.1 Hydrocephalus and Intracranial Pressure Disorder 38
2.2.7.2 Cerebral Edema 39
2.2.8 Indication for Neuromodulation 41
2.2.9 Traumatic brain injury 43
COUNTRY PROFILES 44
3.1 INTRODUCTION 44
3.1.1 Population 44
3.1.2 GDP Per Capita 44
3.1.3 Price Index 44
3.2 GERMANY 45
3.3 FRANCE 46
3.4 UNITED KINGDOM 47
3.5 ITALY 48
3.6 SPAIN 49
3.7 BENELUX 50
3.8 SCANDINAVIA 51
3.9 AUSTRIA 52
3.10 SWITZERLAND 53
3.11 PORTUGAL 54
PRODUCT ASSESSMENT 55
4.1 PRODUCT PORTFOLIOS 55
4.1.1 Neuromodulation Devices 55
4.1.1.1 Introduction 55
4.1.1.2 Spinal Cord Stimulators 55
4.1.1.3 Vagus Nerve Stimulators 56
4.1.1.4 Deep Brain Stimulators 57
4.1.1.5 Gastric Electric Stimulators 59
4.1.1.6 Sacral Nerve Stimulators 59
4.1.1.7 Product Matrix for Neuromodulation Device Market: Core Companies 61
4.2 REGULATORY ISSUES AND RECALLS 62
4.2.1 Neuromodulation Devices 62
4.3 CLINICAL TRIALS 64
4.3.1 Neuromodulation Devices 64
NEUROMODULATION DEVICE MARKET 66
5.1 INTRODUCTION 66
5.1.1 Spinal Cord Stimulators 66
5.1.2 Deep Brain Stimulators 68
5.1.3 Vagus Nerve Stimulators 68
5.1.4 Sacral Nerve Stimulators 69
5.1.5 Gastric Electric Stimulators 70
5.1.6 Intrathecal Pump 71
5.2 MARKET OVERVIEW 73
5.3 MARKET ANALYSIS AND FORECAST 78
5.3.1 Spinal Cord Stimulator Market 78
5.3.2 Deep Brain Stimulator Market 85
5.3.3 Vagus Nerve Stimulator Market 92
5.3.4 Sacral Nerve Stimulator Market 99
5.3.5 Gastric Electric Stimulator Market 106
5.3.6 Intrathecal Pump Market 108
5.4 DRIVERS AND LIMITERS 115
5.4.1 Spinal Cord Stimulator Market 115
5.4.1.1 Market Drivers 115
5.4.1.2 Market Limiters 116
5.4.2 Deep Brain Stimulator Market 118
5.4.2.1 Market Drivers 118
5.4.2.2 Market Limiters 118
5.4.3 Vagus Nerve Stimulator Market 120
5.4.3.1 Market Drivers 120
5.4.3.2 Market Limiters 120
5.4.4 Sacral Nerve Stimulator Market 122
5.4.4.1 Market Drivers 122
5.4.4.2 Market Limiters 122
5.4.5 Gastric Electric Stimulator Market 124
5.4.5.1 Market Drivers 124
5.4.5.2 Market Limiters 124
5.4.6 Intrathecal Pump Market 126
5.4.6.1 Market Drivers 126
5.4.6.2 Market Limiters 127
5.5 COMPETITIVE MARKET SHARE ANALYSIS 129
ABBREVIATIONS 137
APPENDIX: COMPANY PRESS RELEASES 140
Chart 1 1: Neurological Device Market by Segment, Europe, 2013 – 2023 2
Chart 1 2: Neurological Device Market Overview, Europe, 2013 &2023 2
Chart 3 1: Country Profile, Germany, 2016 45
Chart 3 2: Country Profile, France, 2016 46
Chart 3 3: Country Profile, United Kingdom, 2016 47
Chart 3 4: Country Profile, Italy, 2016 48
Chart 3 5: Country Profile, Spain, 2016 49
Chart 3 6: Country Profile, Benelux, 2016 50
Chart 3 7: Country Profile, Scandinavia, 2016 51
Chart 3 8: Country Profile, Austria, 2016 52
Chart 3 9: Country Profile, Switzerland, 2016 53
Chart 3 10: Country Profile, Portugal, 2016 54
Chart 5 1: Neuromodulation Device Market by Segment, Europe, 2013 – 2023 76
Chart 5 2: Neuromodulation Device Market Breakdown, Europe, 2016 77
Chart 5 3: Neuromodulation Device Market Breakdown, Europe, 2023 77
Chart 5 4: Spinal Cord Stimulator Market, Europe, 2013 – 2023 79
Chart 5 5: Deep Brain Stimulator Market, Europe, 2013 – 2023 86
Chart 5 6: Vagus Nerve Stimulator Market, Europe, 2013 – 2023 93
Chart 5 7: Sacral Nerve Stimulator Market, Europe, 2013 – 2023 100
Chart 5 8: Gastric Electric Stimulator Market, Europe, 2013 – 2023 107
Chart 5 9: Intrathecal Pump Market, Europe, 2013 – 2023 109
Chart 5 10: Leading Competitors, Neuromodulation Device Market, Europe, 2016 136
Figure 1 1: Neurological Device Market Share Ranking by Segment, Europe, 2016 (1 of 3) 4
Figure 1 2: Neurological Device Market Share Ranking by Segment, Europe, 2016 (2 of 3) 4
Figure 1 3: Neurological Device Market Share Ranking by Segment, Europe, 2016 (3 of 3) 5
Figure 1 4: Companies Researched in this Report, Europe, 2016 6
Figure 1 5: Factors Impacting the Neurological Device Market by Segment, Europe (1 of 3) 7
Figure 1 6: Factors Impacting the Neurological Device Market by Segment, Europe (2 of 3) 8
Figure 1 7: Factors Impacting the Neurological Device Market by Segment, Europe (3 of 3) 9
Figure 1 8: Recent Events in the Neurological Device Market, Europe, 2014 – 2016 10
Figure 1 9: Neurological Device Markets Covered, Europe, 2016 11
Figure 1 10: Neurological Device Procedures Covered, Europe, 2016 12
Figure 1 11: Key Report Updates 13
Figure 1 12: Version History 13
Figure 2 1: Neurology Disease Overview 29
Figure 2 2: Brain/Other Nervous System Cancer Statistics by Type and Gender, U.S., 2016 33
Figure 4 1: Class 2 Device Recall: RestoreSensor and RestoreSensor SureScan, Medtronic Neuromodulation 62
Figure 4 2: Class 2 Device Recall: DBS Pocket Adaptor, Medtronic Neuromodulation 62
Figure 4 3: Class 2 Device Recall: Specify neurostimulation leads, Medtronic Neuromodulation 62
Figure 4 4: Class 2 Device Recall: Itrel 3 IPG; InterStim II INS: InterStim INS ; Enterra INS 63
Figure 4 5: Class 2 Device Recall: Percutaneous Trial Lead Kits, St. Jude Medical, Inc. 63
Figure 4 6: Class 2 Device Recall: Brio DBS System, Advanced Neuromodulation Systems Inc. 63
Figure 4 7: Class 2 Device Recall: RestoreUltra and RestoreSensor, Medtronic Neuromodulation 63
Figure 4 8: Neuromodulation device: The Motor Network in Essential Tremor: Mechanisms of Therapy 64
Figure 4 9: Neuromodulation device: Treatment of Bipolar Depression With H1-Coil Deep Brain rTMS 64
Figure 4 10: Neuromodulation device: A Pilot Study of Deep Brain Stimulation of the Amygdala 65
Figure 4 11: Neuromodulation device: MAPS Trial: Matrix And Platinum Science (MAPS) 65
Figure 5 1: Neuromodulation Device by Segment, Europe, 2013 – 2023 (€M) 74
Figure 5 2: Neuromodulation Device by Segment, Europe, 2013 – 2023 (US$M) 75
Figure 5 3: Spinal Cord Stimulator Market, Europe, 2013 – 2023 (€ and US$) 79
Figure 5 4: Units Sold by Country, Spinal Cord Stimulator Market, Europe, 2013 – 2023 80
Figure 5 5: Average Selling Price by Country, Spinal Cord Stimulator Market, Europe, 2013 – 2023 (€) 81
Figure 5 6: Average Selling Price by Country, Spinal Cord Stimulator Market, Europe, 2013 – 2023 (US$) 82
Figure 5 7: Market Value by Country, Spinal Cord Stimulator Market, Europe, 2013 – 2023 (€M) 83
Figure 5 8: Market Value by Country, Spinal Cord Stimulator Market, Europe, 2013 – 2023 (US$M) 84
Figure 5 9: Deep Brain Stimulator Market, Europe, 2013 – 2023 (€ and US$) 86
Figure 5 10: Units Sold by Country, Deep Brain Stimulator Market, Europe, 2013 – 2023 87
Figure 5 11: Average Selling Price by Country, Deep Brain Stimulator Market, Europe, 2013 – 2023 (€) 88
Figure 5 12: Average Selling Price by Country, Deep Brain Stimulator Market, Europe, 2013 – 2023 (US$) 89
Figure 5 13: Market Value by Country, Deep Brain Stimulator Market, Europe, 2013 – 2023 (€M) 90
Figure 5 14: Market Value by Country, Deep Brain Stimulator Market, Europe, 2013 – 2023 (US$M) 91
Figure 5 15: Vagus Nerve Stimulator Market, Europe, 2013 – 2023 (€ and US$) 93
Figure 5 16: Units Sold by Country, Vagus Nerve Stimulator Market, Europe, 2013 – 2023 94
Figure 5 17: Average Selling Price by Country, Vagus Nerve Stimulator Market, Europe, 2013 – 2023 (€) 95
Figure 5 18: Average Selling Price by Country, Vagus Nerve Stimulator Market, Europe, 2013 – 2023 (US$) 96
Figure 5 19: Market Value by Country, Vagus Nerve Stimulator Market, Europe, 2013 – 2023 (€M) 97
Figure 5 20: Market Value by Country, Vagus Nerve Stimulator Market, Europe, 2013 – 2023 (US$M) 98
Figure 5 21: Sacral Nerve Stimulator Market, Europe, 2013 – 2023 (€ and US$) 100
Figure 5 22: Units Sold by Country, Sacral Nerve Stimulator Market, Europe, 2013 – 2023 101
Figure 5 23: Average Selling Price by Country, Sacral Nerve Stimulator Market, Europe, 2013 – 2023 (€) 102
Figure 5 24: Average Selling Price by Country, Sacral Nerve Stimulator Market, Europe, 2013 – 2023 (US$) 103
Figure 5 25: Market Value by Country, Sacral Nerve Stimulator Market, Europe, 2013 – 2023 (€M) 104
Figure 5 26: Market Value by Country, Sacral Nerve Stimulator Market, Europe, 2013 – 2023 (US$M) 105
Figure 5 27: Gastric Electric Stimulator Market, Europe, 2013 – 2023 (€ and US$) 106
Figure 5 28: Intrathecal Pump Market, Europe, 2013 – 2023 (€ and US$) 109
Figure 5 29: Units Sold by Country, Intrathecal Pump Market, Europe, 2013 – 2023 110
Figure 5 30: Average Selling Price by Country, Intrathecal Pump Market, Europe, 2013 – 2023 (€) 111
Figure 5 31: Average Selling Price by Country, Intrathecal Pump Market, Europe, 2013 – 2023 (US$) 112
Figure 5 32: Market Value by Country, Intrathecal Pump Market, Europe, 2013 – 2023 (€M) 113
Figure 5 33: Market Value by Country, Intrathecal Pump Market, Europe, 2013 – 2023 (US$M) 114
Figure 5 34: Drivers and Limiters, Spinal Cord Stimulator Market, Europe, 2016 117
Figure 5 35: Drivers and Limiters, Deep Brain Stimulator Market, Europe, 2016 119
Figure 5 36: Drivers and Limiters, Vagus Nerve Stimulator Market, Europe, 2016 121
Figure 5 37: Drivers and Limiters, Sacral Nerve Stimulator Market, Europe, 2016 123
Figure 5 38: Drivers and Limiters, Gastric Electric Stimulator Market, Europe, 2016 125
Figure 5 39: Drivers and Limiters, Intrathecal Pump Market, Europe, 2016 128
Figure 5 40: Leading Competitors, Neuromodulation Device Market, Europe, 2016 (1 of 2) 135
Figure 5 41: Leading Competitors, Neuromodulation Device Market, Europe, 2016 (2 of 2) 135
Figure 7 1: Press Release Summary 140
Medtronic
Stryker
Codman & Shurtleff, Inc.
St. Jude Medical
Nevro
Carl Zeiss
Boston Scientific
LivaNova
Terumo MicroVention
Penumbra Inc.
Leica
Integra LifeSciences
BrainLab
Balt
Magstim
Phenox
MagVenture
Elekta
Moëller Wedel
Misonix
Sophysa
Aesculap
MAG & More
Neurosoft
Acandis
Soring
Brainsway
Nexstim
Others include: ANT, Asahi Intecc, Axonics, Blockade, Dispomedica, Enteromedics, Flowonix, Inomed, Intrapace, Kaneka Medical Products, MHT, Micrus Endovascular, MRC, Navimetric, Neuravi, Neuronetics, Neuropace, NextGen Medicla System, Nuvectra, Scientia Vascular, Spiegelberg, Stimwave, Tokai Medical Product, Tricumed, Vascular Solutions, etc.
