TABLE OF CONTENTS I
LIST OF FIGURES X
LIST OF CHARTS XII
EXECUTIVE SUMMARY 1
EUROPEAN DENTAL BONE GRAFT SUBSTITUTE AND OTHER BIOMATERIALS MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 4
MARKET TRENDS 6
MARKET DEVELOPMENTS 7
PROCEDURES INCLUDED 8
MARKETS INCLUDED 8
VERSION HISTORY 8
RESEARCH METHODOLOGY 9
1.1 RESEARCH SCOPE 9
1.2 IDATA’S 9-STEP METHODOLOGY 9
Step 1: Project Initiation & Team Selection 9
Step 2: Prepare Data Systems and Perform Secondary Research 11
Step 3: Preparation for Interviews & Questionnaire Design 12
Step 4: Performing Primary Research 13
Step 5: Research Analysis: Establishing Baseline Estimates 15
Step 6: Market Forecast and Analysis 16
Step 7: Identify Strategic Opportunities 18
Step 8: Final Review and Market Release 19
Step 9: Customer Feedback and Market Monitoring 20
DISEASE OVERVIEW 21
2.1 BASIC ANATOMY 21
2.1.1 Dental Anatomy: Oral Cavity and Intraoral landmarks 21
2.2 DISEASE PATHOLOGY AND DISORDERS 23
2.2.1 General Diagnostics 23
2.2.2 Indication for Dental Implant 23
2.2.2.1 Periodontal Disease 24
2.2.2.2 Dental Implant Procedures 24
2.3 PATIENT DEMOGRAPHICS 27
2.3.1 General Dental Statistics 27
2.3.2 Tooth Loss Statistics 28
PRODUCT ASSESSMENT 30
3.1 PRODUCT PORTFOLIOS 30
3.1.1 Dental Bone Graft Substitutes 30
3.1.1.1 Dental Growth Factor Products 30
3.2 REGULATORY ISSUES AND RECALLS 32
3.2.1 Dental Bone Graft Substitutes 32
3.3 CLINICAL TRIALS 34
3.3.1 Dental Bone Graft Substitutes 34
COUNTRY PROFILES 37
4.1 INTRODUCTION 37
4.1.1.1 Population 37
4.1.1.2 GDP per Capita 37
4.1.1.3 Dental Bone Graft Substitute Procedures per 10,000 Inhabitants 37
4.1.1.4 Price Index 37
4.2 GERMANY 39
4.3 FRANCE 40
4.4 UNITED KINGDOM 41
4.5 ITALY 42
4.6 SPAIN 43
4.7 BENELUX 44
4.8 SCANDINAVIA 45
4.9 AUSTRIA 46
4.10 SWITZERLAND 47
4.11 PORTUGAL 48
DENTAL GROWTH FACTOR MARKET 49
5.1 INTRODUCTION 49
5.2 MARKET ANALYSIS AND FORECAST 51
5.2.1 Emdogain® Market 51
5.3 DRIVERS AND LIMITERS 59
5.3.1 Market Drivers 59
5.3.2 Market Limiters 59
5.4 EMERGING COMPETITORS AND TECHNOLOGIES 61
5.4.1 GEM 21S® 61
5.4.2 INFUSE® 62
5.4.3 Platelet Rich Plasma (PRP) 62
5.4.4 Osteocel® 63
ABBREVIATIONS 64
APPENDIX: COMPANY PRESS RELEASES 66

Chart 1 1: Dental Bone Graft Substitute and Other Biomaterials Market by Segment, Europe, 2013 – 2023 3
Chart 1 2: Dental Bone Graft Substitute and Other Biomaterials Market Overview, Europe, 2016 & 2023 3
Chart 4 1: Country Profile, Germany, 2016 39
Chart 4 2: Country Profile, France, 2016 40
Chart 4 3: Country Profile, United Kingdom, 2016 41
Chart 4 4: Country Profile, Italy, 2016 42
Chart 4 5: Country Profile, Spain, 2016 43
Chart 4 6: Country Profile, Benelux, 2016 44
Chart 4 7: Country Profile, Scandinavia, 2016 45
Chart 4 8: Country Profile, Austria, 2016 46
Chart 4 9: Country Profile, Switzerland, 2016 47
Chart 4 10: Country Profile, Portugal, 2016 48
Chart 5 1: Emdogain® Market, Europe, 2013 – 2023 53

Figure 1 1: Dental Bone Graft Substitute and Other Biomaterials Market Share Ranking by Segment, Europe, 2016 4
Figure 1 2: Companies Researched in this Report, Europe, 2016 5
Figure 1 3: Factors Impacting the Dental Bone Graft Substitute and Other Biomaterials Market by Segment, Europe 6
Figure 1 4: Recent Events in the Dental Bone Graft Substitute and Other Biomaterials Market, Europe, 2013 – 2016 7
Figure 1 5: Dental Bone Graft Substitute and Other Biomaterials Procedures Covered, Europe, 2016 8
Figure 1 6: Dental Bone Graft Substitute and Other Biomaterials Markets Covered, Europe, 2016 8
Figure 1 7: Version History 8
Figure 3 1: Dental Growth Products by Company 31
Figure 3 2: Class 3 Device Recall ZCORE Syringe 32
Figure 3 3: Class 2 Device Recall Collagen Matrix Inc. 32
Figure 3 4: Class 2 Device Recall Endobon Xenograft Granules, Biomet France SARL 32
Figure 3 5: Class 3 Device Recall ENDOBON XENOGRAFT GRANULES 0.5 ML 33
Figure 3 6: Effect of Mucograft® Seal on Post-extraction Ridge Preservation Using Bone Allograft (Mucograft) 34
Figure 3 7: Prospective, Comparative Assessment of Alveolar Bone Augmentation Using GUIDOR® Membrane 34
Figure 3 8: Evaluation of Zimmer Puros® Allograft vs. Creos™ Allograft for Alveolar Ridge Preservation 35
Figure 3 9: Guided Bone Regeneration Using Synthetic Membrane 35
Figure 3 10: Histological Comparison of Ridge Preservation Using Mineralized FDBA Alone Versus a Combined Mineralized-Demineralized Freeze Dried Bone Allograft 36
Figure 3 11: A Randomized Control Trial Testing Connective Tissue Grafts vs. Allograft on Dental Implants 36
Figure 5 1: Emdogain® Market, Europe, 2013 – 2023 52
Figure 5 2: Units Sold by Country, Emdogain® Market, Europe, 2013 – 2023 54
Figure 5 3: Average Selling Price by Country, Emdogain® Market, Europe, 2013 – 2023 (€) 55
Figure 5 4: Average Selling Price by Country, Emdogain® Market, Europe, 2013 – 2023 (US$) 56
Figure 5 5: Market Value by Country, Emdogain® Market, Europe, 2013 – 2023 (€M) 57
Figure 5 6: Market Value by Country, Emdogain® Market, Europe, 2013 – 2023 (US$M) 58
Figure 5 7: Drivers and Limiters, Dental Growth Factor Market, Europe, 2016 60
Figure 7 1: Press Release Summary 66

Geistlich
Botiss Biomaterials
Zimmer Biomet
Straumann
ACE Surgical
Non-Profit Tissue Banks
Bioteck
Dentegris
Tecnoss Dental
BEGO
Alpha-Bio Tec, Augma Biomaterials, Bicon Dental Implants, Biomatlante, Cortex Dental, Degradable Solutions, Dentsply Sirona, Euroteknika, Implant Direct, Kasios, Keramat, Keystone Dental, MegaGen, MIS Implants, Neoss, Nobel Biocare, Noraker, NovaBone, OT Medical, Resorba and others