General Report Contents
• Market Analyses include: Unit Sales, ASPs, Market Value & Growth Trends
• Market Drivers & Limiters for each chapter segment
• Competitive Analysis for each chapter segment
• Section on recent mergers & acquisitions
The European dental bone graft substitute market can be segmented by material type, yielding three segments: allografts, xenografts and synthetics. As autografts are harvested from a patient and are not necessarily sold within the market, they are not included within the market analysis of the overall DBGS market. Instead, autograft bone materials are considered separately as a potential market. Consumer preferences for less invasive procedures and lower total operation time have lessened the demand for autograft procedures and instead pushed forward the market for DBGS materials.
Further increasing the demand for the DBGS market is growing consumer awareness. Consumer awareness pertains both to dental professionals and patients. In recent years, dental implant companies have invested significant resources in dental implant training programs, which have greatly improved the expertise level of dental professionals conducting dental implant and corresponding DBGS procedures. Dental professionals (including general practitioners) are now better educated of the necessity of sufficient bone quality for a successful implant procedure and the innovative products available on the market. Because they are now better equipped with this knowledge, dental professionals are more likely to recommend patients to undergo a DBGS procedure where necessary. Additionally, a greater pool of dental professionals is now trained and able to conduct DBGS procedures in the market. Patients are now more knowledgeable of the options available to them and the benefits of each and therefore have grown more accepting of procedures that utilize synthetic, animal or other human bone materials as opposed to autograft materials.
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TABLE OF CONTENTS I
LIST OF FIGURES X
LIST OF CHARTS XIII
EXECUTIVE SUMMARY 1
EUROPEAN DENTAL BONE GRAFT SUBSTITUTE AND OTHER BIOMATERIALS MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 4
MARKET TRENDS 6
MARKET DEVELOPMENTS 7
PROCEDURES INCLUDED 8
MARKETS INCLUDED 8
VERSION HISTORY 8
RESEARCH METHODOLOGY 9
1.1 RESEARCH SCOPE 9
1.2 IDATA’S 9-STEP METHODOLOGY 9
Step 1: Project Initiation & Team Selection 9
Step 2: Prepare Data Systems and Perform Secondary Research 11
Step 3: Preparation for Interviews & Questionnaire Design 12
Step 4: Performing Primary Research 13
Step 5: Research Analysis: Establishing Baseline Estimates 15
Step 6: Market Forecast and Analysis 16
Step 7: Identify Strategic Opportunities 18
Step 8: Final Review and Market Release 19
Step 9: Customer Feedback and Market Monitoring 20
DISEASE OVERVIEW 21
2.1 BASIC ANATOMY 21
2.1.1 Dental Anatomy: Oral Cavity and Intraoral landmarks 21
2.2 DISEASE PATHOLOGY AND DISORDERS 23
2.2.1 General Diagnostics 23
2.2.2 Indication for Dental Implant 23
2.2.2.1 Periodontal Disease 24
2.2.2.2 Dental Implant Procedures 24
2.3 PATIENT DEMOGRAPHICS 27
2.3.1 General Dental Statistics 27
2.3.2 Tooth Loss Statistics 28
PRODUCT ASSESSMENT 30
3.1 PRODUCT PORTFOLIOS 30
3.1.1 Dental Bone Graft Substitutes 30
3.1.1.1 Autografts 30
3.1.1.2 Allografts 31
3.1.1.3 Xenografts 33
3.1.1.4 Synthetics 34
3.2 REGULATORY ISSUES AND RECALLS 37
3.2.1 Dental Bone Graft Substitutes 37
3.3 CLINICAL TRIALS 39
3.3.1 Dental Bone Graft Substitutes 39
COUNTRY PROFILES 42
4.1 INTRODUCTION 42
4.1.1.1 Population 42
4.1.1.2 GDP per Capita 42
4.1.1.3 Dental Bone Graft Substitute Procedures per 10,000 Inhabitants 42
4.1.1.4 Price Index 42
4.2 GERMANY 44
4.3 FRANCE 45
4.4 UNITED KINGDOM 46
4.5 ITALY 47
4.6 SPAIN 48
4.7 BENELUX 49
4.8 SCANDINAVIA 50
4.9 AUSTRIA 51
4.10 SWITZERLAND 52
4.11 PORTUGAL 53
DENTAL BONE GRAFT SUBSTITUTE MARKET 54
5.1 INTRODUCTION 54
5.1.1 Autografts 54
5.1.2 Allografts 55
5.1.2.1 Mineralized Allografts 55
5.1.2.2 Demineralized Bone Matrix Allografts 56
5.1.3 Xenografts 56
5.1.4 Synthetics 57
5.2 MARKET OVERVIEW 58
5.3 MARKET ANALYSIS AND FORECAST 63
5.3.1 Total Dental Bone Graft Substitute Market 63
5.3.2 Total Allograft Market 71
5.3.2.1 Mineralized Allograft Market 80
5.3.2.2 Demineralized Bone Matrix Allograft Market 87
5.3.3 Xenograft Market 95
5.3.4 Synthetic Market 103
5.4 DRIVERS AND LIMITERS 111
5.4.1 Market Drivers 111
5.4.2 Market Limiters 113
5.5 COMPETITIVE MARKET SHARE ANALYSIS 116
ABBREVIATIONS 134
APPENDIX: COMPANY PRESS RELEASES 136
Chart 1 1: Dental Bone Graft Substitute and Other Biomaterials Market by Segment, Europe, 2013 – 2023 3
Chart 1 2: Dental Bone Graft Substitute and Other Biomaterials Market Overview, Europe, 2016 & 2023 3
Chart 4 1: Country Profile, Germany, 2016 44
Chart 4 2: Country Profile, France, 2016 45
Chart 4 3: Country Profile, United Kingdom, 2016 46
Chart 4 4: Country Profile, Italy, 2016 47
Chart 4 5: Country Profile, Spain, 2016 48
Chart 4 6: Country Profile, Benelux, 2016 49
Chart 4 7: Country Profile, Scandinavia, 2016 50
Chart 4 8: Country Profile, Austria, 2016 51
Chart 4 9: Country Profile, Switzerland, 2016 52
Chart 4 10: Country Profile, Portugal, 2016 53
Chart 5 1: Dental Bone Graft Substitute Market by Segment, Europe, 2013 – 2023 61
Chart 5 2: Dental Bone Graft Substitute Market Breakdown, Europe, 2016 62
Chart 5 3: Dental Bone Graft Substitute Market Breakdown, Europe, 2023 62
Chart 5 4: Total Dental Bone Graft Substitute Market, Europe, 2013 – 2023 65
Chart 5 5: Total Allograft Market, Europe, 2013 – 2023 74
Chart 5 6: Mineralized Allograft Market, Europe, 2013 – 2023 81
Chart 5 7: Demineralized Bone Matrix Allograft Market, Europe, 2013 – 2023 89
Chart 5 8: Xenograft Market, Europe, 2013 – 2023 97
Chart 5 9: Synthetic Market, Europe, 2013 – 2023 105
Chart 5 10: Leading Competitors, Dental Bone Graft Substitute Market, Europe, 2016 125
Chart 5 11: Leading Competitors, Total Dental Bone Graft Substitute Market, Europe, 2016 127
Chart 5 12: Leading Competitors, Allograft Market, Europe, 2016 129
Chart 5 13: Leading Competitors, Xenograft Market, Europe, 2016 131
Chart 5 14: Leading Competitors, Synthetic Market, Europe, 2016 133
Figure 1 1: Dental Bone Graft Substitute and Other Biomaterials Market Share Ranking by Segment, Europe, 2016 4
Figure 1 2: Companies Researched in this Report, Europe, 2016 5
Figure 1 3: Factors Impacting the Dental Bone Graft Substitute and Other Biomaterials Market by Segment, Europe 6
Figure 1 4: Recent Events in the Dental Bone Graft Substitute and Other Biomaterials Market, Europe, 2013 – 2016 7
Figure 1 5: Dental Bone Graft Substitute and Other Biomaterials Procedures Covered, Europe, 2016 8
Figure 1 6: Dental Bone Graft Substitute and Other Biomaterials Markets Covered, Europe, 2016 8
Figure 1 7: Version History 8
Figure 3 1: Dental Bone Graft Substitute Products by Company (1 of 2) 35
Figure 3 2: Dental Bone Graft Substitute Products by Company (2 of 2) 36
Figure 3 3: Class 3 Device Recall ZCORE Syringe 37
Figure 3 4: Class 2 Device Recall Collagen Matrix Inc. 37
Figure 3 5: Class 2 Device Recall Endobon Xenograft Granules, Biomet France SARL 37
Figure 3 6: Class 3 Device Recall ENDOBON XENOGRAFT GRANULES 0.5 ML 38
Figure 3 7: Effect of Mucograft® Seal on Post-extraction Ridge Preservation Using Bone Allograft (Mucograft) 39
Figure 3 8: Prospective, Comparative Assessment of Alveolar Bone Augmentation Using GUIDOR® Membrane 39
Figure 3 9: Evaluation of Zimmer Puros® Allograft vs. Creos™ Allograft for Alveolar Ridge Preservation 40
Figure 3 10: Guided Bone Regeneration Using Synthetic Membrane 40
Figure 3 11: Histological Comparison of Ridge Preservation Using Mineralized FDBA Alone Versus a Combined Mineralized-Demineralized Freeze Dried Bone Allograft 41
Figure 3 12: A Randomized Control Trial Testing Connective Tissue Grafts vs. Allograft on Dental Implants 41
Figure 5 1: Dental Bone Graft Substitute Market by Segment, Europe, 2013 – 2023 (€M) 60
Figure 5 2: Dental Bone Graft Substitute Market by Segment, Europe, 2013 – 2023 (US$M) 60
Figure 5 3: Total Dental Bone Graft Substitute Market, Europe, 2013 – 2023 64
Figure 5 4: Units Sold (cc) by Country, Total Dental Bone Graft Substitute Market, Europe, 2013 – 2023 66
Figure 5 5: Average Selling Price by Country, Total Dental Bone Graft Substitute Market, Europe, 2013 – 2023 (€) 67
Figure 5 6: Average Selling Price by Country, Total Dental Bone Graft Substitute Market, Europe, 2013 – 2023 (US$) 68
Figure 5 7: Market Value by Country, Total Dental Bone Graft Substitute Market, Europe, 2013 – 2023 (€M) 69
Figure 5 8: Market Value by Country, Total Dental Bone Graft Substitute Market, Europe, 2013 – 2023 (US$M) 70
Figure 5 9: Total Allograft Market, Europe, 2013 – 2023 73
Figure 5 10: Units Sold (cc) by Country, Total Allograft Market, Europe, 2013 – 2023 75
Figure 5 11: Average Selling Price by Country, Total Allograft Market, Europe, 2013 – 2023 (€) 76
Figure 5 12: Average Selling Price by Country, Total Allograft Market, Europe, 2013 – 2023 (US$) 77
Figure 5 13: Market Value by Country, Total Allograft Market, Europe, 2013 – 2023 (€M) 78
Figure 5 14: Market Value by Country, Total Allograft Market, Europe, 2013 – 2023 (US$M) 79
Figure 5 15: Mineralized Allograft Market, Europe, 2013 – 2023 80
Figure 5 16: Units Sold (cc) by Country, Mineralized Allograft Market, Europe, 2013 – 2023 82
Figure 5 17: Average Selling Price by Country, Mineralized Allograft Market, Europe, 2013 – 2023 (€) 83
Figure 5 18: Average Selling Price by Country, Mineralized Allograft Market, Europe, 2013 – 2023 (US$) 84
Figure 5 19: Market Value by Country, Mineralized Allograft Market, Europe, 2013 – 2023 (€M) 85
Figure 5 20: Market Value by Country, Mineralized Allograft Market, Europe, 2013 – 2023 (US$M) 86
Figure 5 21: Demineralized Bone Matrix Allograft Market, Europe, 2013 – 2023 88
Figure 5 22: Units Sold (cc) by Country, Demineralized Bone Matrix Allograft Market, Europe, 2013 – 2023 90
Figure 5 23: Average Selling Price by Country, Demineralized Bone Matrix Allograft Market, Europe, 2013 – 2023 (€) 91
Figure 5 24: Average Selling Price by Country, Demineralized Bone Matrix Allograft Market, Europe, 2013 – 2023 (US$) 92
Figure 5 25: Market Value by Country, Demineralized Bone Matrix Allograft Market, Europe, 2013 – 2023 (€M) 93
Figure 5 26: Market Value by Country, Demineralized Bone Matrix Allograft Market, Europe, 2013 – 2023 (US$M) 94
Figure 5 27: Xenograft Market, Europe, 2013 – 2023 96
Figure 5 28: Units Sold (cc) by Country, Xenograft Market, Europe, 2013 – 2023 98
Figure 5 29: Average Selling Price by Country, Xenograft Market, Europe, 2013 – 2023 (€) 99
Figure 5 30: Average Selling Price by Country, Xenograft Market, Europe, 2013 – 2023 (US$) 100
Figure 5 31: Market Value by Country, Xenograft Market, Europe, 2013 – 2023 (€M) 101
Figure 5 32: Market Value by Country, Xenograft Market, Europe, 2013 – 2023 (US$M) 102
Figure 5 33: Synthetic Market, Europe, 2013 – 2023 104
Figure 5 34: Units Sold (cc) by Country, Synthetic Market, Europe, 2013 – 2023 106
Figure 5 35: Average Selling Price by Country, Synthetic Market, Europe, 2013 – 2023 (€) 107
Figure 5 36: Average Selling Price by Country, Synthetic Market, Europe, 2013 – 2023 (US$) 108
Figure 5 37: Market Value by Country, Synthetic Market, Europe, 2013 – 2023 (€M) 109
Figure 5 38: Market Value by Country, Synthetic Market, Europe, 2013 – 2023 (US$M) 110
Figure 5 39: Drivers and Limiters, Dental Bone Graft Substitute Market, Europe, 2016 115
Figure 5 40: Leading Competitors, Dental Bone Graft Substitute Market, Europe, 2016 124
Figure 5 41: Leading Competitors, Total Dental Bone Graft Substitute Market, Europe, 2016 126
Figure 5 42: Leading Competitors, Allograft Market, Europe, 2016 128
Figure 5 43: Leading Competitors, Xenograft Market, Europe, 2016 130
Figure 5 44: Leading Competitors, Synthetic Market, Europe, 2016 132
Figure 7 1: Press Release Summary 136
Geistlich
Botiss Biomaterials
Zimmer Biomet
Straumann
ACE Surgical
Non-Profit Tissue Banks
Bioteck
Dentegris
Tecnoss Dental
BEGO
Alpha-Bio Tec, Augma Biomaterials, Bicon Dental Implants, Biomatlante, Cortex Dental, Degradable Solutions, Dentsply Sirona, Euroteknika, Implant Direct, Kasios, Keramat, Keystone Dental, MegaGen, MIS Implants, Neoss, Nobel Biocare, Noraker, NovaBone, OT Medical, Resorba and others
