TABLE OF CONTENTS I
LIST OF FIGURES XVIII
LIST OF CHARTS XX
EXECUTIVE SUMMARY 1
U.S. ORTHOPEDIC BIOMATERIALS MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 4
MARKET TRENDS 6
MARKET DEVELOPMENTS 8
PROCEDURE NUMBERS 9
MARKETS INCLUDED 11
KEY REPORT UPDATES 13
VERSION HISTORY 13
RESEARCH METHODOLOGY 14
1.1 RESEARCH SCOPE 14
1.2 IDATA’S 9-STEP METHODOLOGY 14
Step 1: Project Initiation & Team Selection 14
Step 2: Prepare Data Systems and Perform Secondary Research 16
Step 3: Preparation for Interviews & Questionnaire Design 17
Step 4: Performing Primary Research 18
Step 5: Research Analysis: Establishing Baseline Estimates 20
Step 6: Market Forecast and Analysis 21
Step 7: Identify Strategic Opportunities 23
Step 8: Final Review and Market Release 24
Step 9: Customer Feedback and Market Monitoring 25
DISEASE OVERVIEW 26
2.1 BASIC ANATOMY 26
2.1.1 Osteology and Musculoskeletal System 26
2.2 DISEASE PATHOLOGY AND DISORDERS 28
2.2.1 General Diagnostic 28
2.2.2 Osteoporosis 29
2.2.3 Osteoarthritis 29
2.2.4 Indication for Bone Graft Procedure 30
2.2.5 Indication for Cartilage Repair 31
2.2.6 Degenerative Disc Disease 32
2.3 PATIENT DEMOGRAPHICS 34
2.3.1 General Statistics 34
PRODUCT ASSESSMENT 36
3.1 PRODUCT PORTFOLIOS 36
3.1.1 Cartilage Repair 37
3.2 REGULATORY ISSUES AND RECALLS 39
3.2.1 Cartilage Repair 39
3.3 CLINICAL TRIALS 40
3.3.1 Cartilage Repair 40
ORTHOPEDIC CARTILAGE REPAIR MARKET 45
4.1 INTRODUCTION 45
4.1.1 Anatomy 45
4.1.2 Methods for Cartilage Repair 45
4.1.2.1 Microfracture 45
4.1.2.2 Microfracture Adjunct 46
4.1.2.3 Osteoarticular Autograft Transfer System 46
4.1.2.4 Particulated Juvenile Allograft 46
4.1.2.5 Osteochondral Allograft Transfer 46
4.1.2.6 Autologous Chondrocyte Implantation 47
4.1.2.7 Meniscal Allograft Transplantation 47
4.2 MARKET OVERVIEW 48
4.3 MARKET ANALYSIS AND FORECAST 52
4.3.1 Osteochondral Allograft Market 52
4.3.2 Meniscal Allograft Market 54
4.3.3 Autologous Chondrocyte Implantation Market 56
4.3.4 Particulated Juvenile Allograft Implant Market 58
4.3.5 Microfracture Adjunct Market 60
4.4 DRIVERS AND LIMITERS 62
4.4.1 Market Drivers 62
4.4.2 Market Limiters 62
4.5 COMPETITIVE MARKET SHARE ANALYSIS 64
ABBREVIATIONS 68
APPENDIX II: COMPANY PRESS RELEASES 70

Chart 1 1: Orthopedic Biomaterials Market by Segment, U.S., 2013 – 2023 3
Chart 1 2: Orthopedic Biomaterials Market Overview, U.S., 2016 & 2023 3
Chart 4 1: Orthopedic Cartilage Repair Market by Segment, U.S., 2013 – 2023 50
Chart 4 2: Orthopedic Cartilage Repair Market Breakdown, U.S., 2016 51
Chart 4 3: Orthopedic Cartilage Repair Market Breakdown, U.S., 2023 51
Chart 4 4: Osteochondral Allograft Market, U.S., 2013 – 2023 53
Chart 4 5: Meniscal Allograft Market, U.S., 2013 – 2023 55
Chart 4 6: Autologous Chondrocyte Implantation Market, U.S., 2013 – 2023 57
Chart 4 7: Particulated Juvenile Allograft Implant Market, U.S., 2013 – 2023 59
Chart 4 8: Microfracture Adjunct Market, U.S., 2013 – 2023 61
Chart 4 9: Leading Competitors, Orthopedic Cartilage Repair Market, U.S., 2016 67

Figure 1 1: Orthopedic Biomaterials Market Share Ranking by Segment, U.S., 2016 (1 of 2) 4
Figure 1 2: Orthopedic Biomaterials Market Share Ranking by Segment, U.S., 2016 (2 of 2) 4
Figure 1 3: Companies Researched in this Report, U.S., 2016 5
Figure 1 4: Factors Impacting the Orthopedic Biomaterials Market by Segment, U.S. (1 of 2) 6
Figure 1 5: Factors Impacting the Orthopedic Biomaterials Market by Segment, U.S. (2 of 2) 7
Figure 1 6: Recent Events in the Orthopedic Biomaterials Market, U.S., 2013 – 2016 8
Figure 1 7: Orthopedic Biomaterials Markets Covered, U.S., 2016 (1 of 2) 9
Figure 1 8: Orthopedic Biomaterials Markets Covered, U.S., 2016 (2 of 2) 10
Figure 1 9: Orthopedic Biomaterials Markets Covered, U.S., 2016(1 of 3) 11
Figure 3 1: Cartilage Repair Products by Company 38
Figure 3 2: Class 2 Device Recall Smith & Nephew 39
Figure 3 3: Class 2 Device Recall Surgical Saw Blade Procedure Pack 39
Figure 3 4: DeNovo NT Longitudinal Data Collection (LDC) Knee Study 40
Figure 3 5: NOVOCART®3D for Treatment of Articular Cartilage of the Knee (N3D) 40
Figure 3 6: Porous Tissue Regenerative Silk Scaffold for Human Meniscal Cartilage Repair (REKREATE) 41
Figure 3 7: Confirmatory Study of NeoCart in Knee Cartilage Repair 41
Figure 3 8: the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Ankle 42
Figure 3 9: Efficacy of BST-CarGel in Treating Chondral Lesions of the Hip 42
Figure 3 10: BiPhasic Cartilage Repair Implant (BiCRI) IDE Clinical Trial - Taiwan 43
Figure 3 11: A Study to Compare Two Techniques for Articular Cartilage Repair:ACIC Vs. MCIC 43
Figure 3 12: Second Line Treatment of Knee Osteochondral Lesion With Treated Osteochondral Graft (ODPHOENIX2) 44
Figure 3 13: Neocartilage Implant to Treat Cartilage Lesions of the Knee 44
Figure 4 1: Orthopedic Cartilage Repair Market by Segment, U.S., 2013 – 2023 (US$M) 49
Figure 4 2: Osteochondral Allograft Market, U.S., 2013 – 2023 52
Figure 4 3: Meniscal Allograft Market, U.S., 2013 – 2023 54
Figure 4 4: Autologous Chondrocyte Implantation Market, U.S., 2013 – 2023 56
Figure 4 5: Particulated Juvenile Allograft Implant Market, U.S., 2013 – 2023 58
Figure 4 6: Microfracture Adjunct Market, U.S., 2013 – 2023 60
Figure 4 7: Drivers and Limiters, Orthopedic Cartilage Repair Market, U.S., 2016 63
Figure 4 8: Leading Competitors, Orthopedic Cartilage Repair Market, U.S., 2016 66
Figure 6 1: Press Release Summary 70

Medtronic
Genzyme
DePuy Synthes
Anika Therapeutics
Ferring Pharmaceuticals
Stryker
NuVasive
Bioventus
Zimmer Biomet
Integra LifeSciences
RTI Surgical
Fidia Pharmaceuticals
MTF
Orthofix
Arthrex
AlloSource
Aastrom
Baxter
Harvest Technologies
Wright Medical
Bacterin International
Arteriocyte
Exactech
LifeNet Health
Biocomposites
Alphatec Spine
Celling Biosciences
Globus Medical
Nuo Therapeutics
K2M
*Not all companies are currently active in every segment or sub-report from this suite. For more details contact an iData Research Product Advisor.