TABLE OF CONTENTS I
LIST OF FIGURES IX
LIST OF CHARTS X
EXECUTIVE SUMMARY 1
U.S. NEUROMODULATION, NEUROVASCULAR, NEUROSURGICAL AND MONITORING DEVICE MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 4
MARKET TRENDS 8
MARKET DEVELOPMENTS 11
PROCEDURE NUMBERS 12
PROCEDURE CODES INVESTIGATED 13
MARKETS INCLUDED 15
KEY REPORT UPDATES 17
VERSION HISTORY 17
RESEARCH METHODOLOGY 18
1.1 RESEARCH SCOPE 18
1.2 IDATA’S 9-STEP METHODOLOGY 18
Step 1: Project Initiation & Team Selection 18
Step 2: Prepare Data Systems and Perform Secondary Research 20
Step 3: Preparation for Interviews & Questionnaire Design 21
Step 4: Performing Primary Research 22
Step 5: Research Analysis: Establishing Baseline Estimates 24
Step 6: Market Forecast and Analysis 25
Step 7: Identify Strategic Opportunities 27
Step 8: Final Review and Market Release 28
Step 9: Customer Feedback and Market Monitoring 29
DISEASE OVERVIEW 30
2.1 BASIC ANATOMY 30
2.2 DISEASE PATHOLOGY AND DISORDERS 32
2.2.1 Introduction 32
2.2.2 General Diagnostics and Neurosurgery 34
2.2.3 Tumor and Brain Cancer 36
2.2.4 Brain Arteriovenous Malformations 38
2.2.5 Ischemic Stroke 39
2.2.6 Brain Aneurysm 40
2.2.7 Disorders Related to Cerebrospinal Fluids and Intracranial Pressure 42
2.2.7.1 Hydrocephalus and Intracranial Pressure Disorder 42
2.2.7.2 Cerebral Edema 43
2.2.8 Indication for Neuromodulation 45
2.2.9 Traumatic brain injury 47
PRODUCT ASSESSMENT 48
3.1 PRODUCT PORTFOLIOS 48
3.1.1 Liquid Embolics 48
3.1.1.1 Introduction 48
3.1.1.2 Product Matrix for Liquid Embolics Market: Core Companies 50
3.2 REGULATORY ISSUES AND RECALLS 51
3.2.1 Liquid Embolics 51
3.3 CLINICAL TRIALS 52
3.3.1 Liquid Embolic 52
LIQUID EMBOLIC MARKET 53
4.1 INTRODUCTION 53
4.2 MARKET ANALYSIS AND FORECAST 55
4.3 DRIVERS AND LIMITERS 57
4.3.1 Market Drivers 57
4.3.2 Market Limiters 57
4.4 COMPETITIVE MARKET SHARE ANALYSIS 60
ABBREVIATIONS 63
APPENDIX: COMPANY PRESS RELEASES 66

Chart 1 1: Neurological Device Market by Segment, U.S., 2013 – 2023 3
Chart 1 2: Neurological Device Market Overview, U.S., 2016 & 2023 3
Chart 4 1: Liquid Embolic Market, U.S., 2013 – 2023 56
Chart 4 2: Leading Competitors, Liquid Embolic Market, U.S., 2016 62

Figure 1 1: Neurological Device Market Share Ranking by Segment, U.S., 2016 (1 of 3) 5
Figure 1 2: Neurological Device Market Share Ranking by Segment, U.S., 2016 (2 of 3) 5
Figure 1 3: Neurological Device Market Share Ranking by Segment, U.S., 2016 (3 of 3) 6
Figure 1 4: Companies Researched in this Report, U.S., 2016 7
Figure 1 5: Factors Impacting the Neurological Device Market by Segment, U.S. (1 of 3) 8
Figure 1 6: Factors Impacting the Neurological Device Market by Segment, U.S. (2 of 3) 9
Figure 1 7: Factors Impacting the Neurological Device Market by Segment, U.S. (3 of 3) 10
Figure 1 8: Recent Events in the Neurological Device Market, U.S., 2014 – 2016 11
Figure 1 9: Neurological Device Markets Covered, U.S., 2016 12
Figure 1 10: Procedural Codes Investigated, U.S., 2016 (1 of 2) 13
Figure 1 11: Procedural Codes Investigated, U.S., 2016 (2 of 2) 14
Figure 1 12: Neurological Device Markets Covered, U.S., 2016 (1 of 2) 15
Figure 1 13: Neurological Device Markets Covered, U.S., 2016 (2 of 2) 16
Figure 1 14: Key Report Updates 17
Figure 1 15: Version History 17
Figure 2 1: Neurology Disease Overview 33
Figure 2 2: Brain/Other Nervous System Cancer Statistics by Type and Gender, U.S., 2016 37
Figure 3 1: Class 1 Device Recall: nButyl Cyanoacrylate (nBCA) Liquid Embolic System (TRUFILL, Codman) 51
Figure 3 2: Liquid Embolic: Apollo™ Onyx™ Delivery Micro Catheter Post Market Safety Study 52
Figure 3 3: Liquid Embolic: Safety of Apollo Micro Catheter in Pediatric Patients 52
Figure 3 4: Liquid Embolic: TRUfill®'s Line in Intracranial aNeurysm Embolisation (TRULINE) 52
Figure 4 1: Liquid Embolic Market, U.S., 2013 – 2023 55
Figure 4 2: Drivers and Limiters, Liquid Embolic Market, U.S., 2016 59
Figure 4 3: Leading Competitors, Liquid Embolic Market, U.S., 2016 61
Figure 6 1: Press Release Summary 66

Medtronic
Boston Scientific
St. Jude Medical
Cyberonics
Codman & Shurtleff
Stryker
Integra LifeSciences
InoMed
Mizuho America
RauMedic